Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3495644..3496122 Replicon chromosome
Accession NZ_CP032811
Organism Escherichia coli strain ERL03-1416

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag D8Z67_RS18275 Protein ID WP_001303876.1
Coordinates 3495835..3496122 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag D8Z67_RS18270 Protein ID WP_000536233.1
Coordinates 3495644..3495835 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z67_RS18235 3491048..3491818 - 771 WP_000450992.1 DUF1627 domain-containing protein -
D8Z67_RS18240 3491840..3492586 - 747 WP_000788745.1 ATP-binding protein -
D8Z67_RS18245 3492593..3493684 - 1092 WP_001205823.1 hypothetical protein -
D8Z67_RS18250 3493763..3494218 + 456 WP_000273724.1 hypothetical protein -
D8Z67_RS18255 3494425..3494850 - 426 WP_000693855.1 Rha family transcriptional regulator -
D8Z67_RS18260 3494834..3495106 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
D8Z67_RS18265 3495215..3495616 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
D8Z67_RS18270 3495644..3495835 + 192 WP_000536233.1 hypothetical protein Antitoxin
D8Z67_RS18275 3495835..3496122 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D8Z67_RS18285 3496400..3496555 + 156 WP_000379575.1 DUF1391 family protein -
D8Z67_RS18290 3496697..3497086 + 390 WP_000394511.1 hypothetical protein -
D8Z67_RS18295 3497273..3497458 - 186 WP_001133046.1 hypothetical protein -
D8Z67_RS18305 3498032..3498220 + 189 WP_000413705.1 cell division inhibition protein DicB -
D8Z67_RS18310 3498217..3498408 + 192 WP_001098307.1 DUF1482 family protein -
D8Z67_RS18315 3498502..3500973 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T112568 WP_001303876.1 NZ_CP032811:3495835-3496122 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T112568 NZ_CP032811:3495835-3496122 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT112568 WP_000536233.1 NZ_CP032811:3495644-3495835 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT112568 NZ_CP032811:3495644-3495835 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References