Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3585073..3585551 Replicon chromosome
Accession NZ_CP032801
Organism Escherichia coli strain ERL06-2442

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag D8Z71_RS18980 Protein ID WP_001303876.1
Coordinates 3585264..3585551 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag D8Z71_RS18975 Protein ID WP_000536233.1
Coordinates 3585073..3585264 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z71_RS18940 3580477..3581247 - 771 WP_000450992.1 DUF1627 domain-containing protein -
D8Z71_RS18945 3581269..3582015 - 747 WP_000788745.1 ATP-binding protein -
D8Z71_RS18950 3582022..3583113 - 1092 WP_001205823.1 hypothetical protein -
D8Z71_RS18955 3583192..3583647 + 456 WP_000273724.1 hypothetical protein -
D8Z71_RS18960 3583854..3584279 - 426 WP_000693855.1 Rha family transcriptional regulator -
D8Z71_RS18965 3584263..3584535 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
D8Z71_RS18970 3584644..3585045 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
D8Z71_RS18975 3585073..3585264 + 192 WP_000536233.1 hypothetical protein Antitoxin
D8Z71_RS18980 3585264..3585551 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D8Z71_RS18990 3585829..3585984 + 156 WP_000379575.1 DUF1391 family protein -
D8Z71_RS18995 3586126..3586515 + 390 WP_000394511.1 hypothetical protein -
D8Z71_RS19000 3586702..3586887 - 186 WP_001133046.1 hypothetical protein -
D8Z71_RS19010 3587461..3587649 + 189 WP_000413705.1 cell division inhibition protein DicB -
D8Z71_RS19015 3587646..3587837 + 192 WP_001098307.1 DUF1482 family protein -
D8Z71_RS19020 3587931..3590402 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T112421 WP_001303876.1 NZ_CP032801:3585264-3585551 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T112421 NZ_CP032801:3585264-3585551 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT112421 WP_000536233.1 NZ_CP032801:3585073-3585264 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT112421 NZ_CP032801:3585073-3585264 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References