Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3595453..3595931 Replicon chromosome
Accession NZ_CP032797
Organism Escherichia coli strain ERL06-2497

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag D8Z72_RS19160 Protein ID WP_001303876.1
Coordinates 3595644..3595931 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag D8Z72_RS19155 Protein ID WP_000536233.1
Coordinates 3595453..3595644 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z72_RS19120 3590857..3591627 - 771 WP_000450992.1 DUF1627 domain-containing protein -
D8Z72_RS19125 3591649..3592395 - 747 WP_000788751.1 ATP-binding protein -
D8Z72_RS19130 3592402..3593493 - 1092 WP_001205823.1 hypothetical protein -
D8Z72_RS19135 3593572..3594027 + 456 WP_000273724.1 hypothetical protein -
D8Z72_RS19140 3594234..3594659 - 426 WP_000693855.1 Rha family transcriptional regulator -
D8Z72_RS19145 3594643..3594915 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
D8Z72_RS19150 3595024..3595425 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
D8Z72_RS19155 3595453..3595644 + 192 WP_000536233.1 hypothetical protein Antitoxin
D8Z72_RS19160 3595644..3595931 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D8Z72_RS19170 3596209..3596364 + 156 WP_000379575.1 DUF1391 family protein -
D8Z72_RS19175 3596506..3596895 + 390 WP_000394511.1 hypothetical protein -
D8Z72_RS19180 3597082..3597267 - 186 WP_001133046.1 hypothetical protein -
D8Z72_RS19190 3597841..3598029 + 189 WP_000413705.1 cell division inhibition protein DicB -
D8Z72_RS19195 3598026..3598217 + 192 WP_001098307.1 DUF1482 family protein -
D8Z72_RS19200 3598311..3600782 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T112380 WP_001303876.1 NZ_CP032797:3595644-3595931 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T112380 NZ_CP032797:3595644-3595931 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT112380 WP_000536233.1 NZ_CP032797:3595453-3595644 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT112380 NZ_CP032797:3595453-3595644 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References