Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3362235..3362713 Replicon chromosome
Accession NZ_CP032793
Organism Escherichia coli strain NZRM3614

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag D8Z74_RS17455 Protein ID WP_001303876.1
Coordinates 3362426..3362713 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag D8Z74_RS17450 Protein ID WP_000536233.1
Coordinates 3362235..3362426 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z74_RS17415 3357639..3358409 - 771 WP_000450992.1 DUF1627 domain-containing protein -
D8Z74_RS17420 3358431..3359177 - 747 WP_000788751.1 ATP-binding protein -
D8Z74_RS17425 3359184..3360275 - 1092 WP_001205823.1 hypothetical protein -
D8Z74_RS17430 3360354..3360809 + 456 WP_000273724.1 hypothetical protein -
D8Z74_RS17435 3361016..3361441 - 426 WP_000693855.1 Rha family transcriptional regulator -
D8Z74_RS17440 3361425..3361697 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
D8Z74_RS17445 3361806..3362207 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
D8Z74_RS17450 3362235..3362426 + 192 WP_000536233.1 hypothetical protein Antitoxin
D8Z74_RS17455 3362426..3362713 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D8Z74_RS17465 3362991..3363146 + 156 WP_000379575.1 DUF1391 family protein -
D8Z74_RS17470 3363288..3363677 + 390 WP_000394511.1 hypothetical protein -
D8Z74_RS17475 3363864..3364049 - 186 WP_001133046.1 hypothetical protein -
D8Z74_RS17485 3364623..3364811 + 189 WP_000413705.1 cell division inhibition protein DicB -
D8Z74_RS17490 3364808..3364999 + 192 WP_001098307.1 DUF1482 family protein -
D8Z74_RS17495 3365093..3367564 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T112313 WP_001303876.1 NZ_CP032793:3362426-3362713 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T112313 NZ_CP032793:3362426-3362713 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT112313 WP_000536233.1 NZ_CP032793:3362235-3362426 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT112313 NZ_CP032793:3362235-3362426 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References