Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3488350..3488828 Replicon chromosome
Accession NZ_CP032791
Organism Escherichia coli strain NZRM4165

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag D8Z75_RS18340 Protein ID WP_001303876.1
Coordinates 3488541..3488828 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag D8Z75_RS18335 Protein ID WP_000536233.1
Coordinates 3488350..3488541 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z75_RS18300 3483754..3484524 - 771 WP_000450992.1 DUF1627 domain-containing protein -
D8Z75_RS18305 3484546..3485292 - 747 WP_000788751.1 ATP-binding protein -
D8Z75_RS18310 3485299..3486390 - 1092 WP_001205823.1 hypothetical protein -
D8Z75_RS18315 3486469..3486924 + 456 WP_000273724.1 hypothetical protein -
D8Z75_RS18320 3487131..3487556 - 426 WP_000693855.1 Rha family transcriptional regulator -
D8Z75_RS18325 3487540..3487812 - 273 WP_032362955.1 helix-turn-helix domain-containing protein -
D8Z75_RS18330 3487921..3488322 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
D8Z75_RS18335 3488350..3488541 + 192 WP_000536233.1 hypothetical protein Antitoxin
D8Z75_RS18340 3488541..3488828 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D8Z75_RS18350 3489106..3489261 + 156 WP_000379575.1 DUF1391 family protein -
D8Z75_RS18355 3489403..3489792 + 390 WP_000394511.1 hypothetical protein -
D8Z75_RS18360 3489979..3490164 - 186 WP_001133046.1 hypothetical protein -
D8Z75_RS18370 3490738..3490926 + 189 WP_000413705.1 cell division inhibition protein DicB -
D8Z75_RS18375 3490923..3491114 + 192 WP_001098307.1 DUF1482 family protein -
D8Z75_RS18380 3491208..3493679 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T112276 WP_001303876.1 NZ_CP032791:3488541-3488828 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T112276 NZ_CP032791:3488541-3488828 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT112276 WP_000536233.1 NZ_CP032791:3488350-3488541 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT112276 NZ_CP032791:3488350-3488541 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References