112206

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 4507186..4508407 Replicon chromosome
Accession NZ_CP032761
Organism Pseudomonas aeruginosa strain 268

Toxin (Protein)


Gene name vapC Uniprot ID V6AG16
Locus tag PA268_RS21795 Protein ID WP_003088107.1
Coordinates 4507186..4507764 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PA268_RS21800 Protein ID WP_003088112.1
Coordinates 4507853..4508407 (-) Length 185 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA268_RS21780 4502462..4503739 + 1278 WP_003088104.1 TolC family protein -
PA268_RS21785 4503729..4505900 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
PA268_RS21790 4505890..4507077 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
PA268_RS21795 4507186..4507764 - 579 WP_003088107.1 HD domain-containing protein Toxin
PA268_RS21800 4507853..4508407 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
PA268_RS21805 4508565..4510760 - 2196 WP_003088114.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PA268_RS21810 4510765..4511226 - 462 WP_003088117.1 (2Fe-2S)-binding protein -
PA268_RS21815 4511557..4511880 + 324 WP_003102734.1 multidrug efflux SMR transporter -
PA268_RS21820 4511893..4512291 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PA268_RS21825 4512288..4512839 - 552 WP_023098678.1 XRE family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-187)

Antitoxin

(14-62)


Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21885.74 Da        Isoelectric Point: 5.3655

>T112206 WP_003088107.1 NZ_CP032761:c4507764-4507186 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Download         Length: 579 bp

>T112206 NZ_CP032761:c4507764-4507186 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAAGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT112206 WP_003088112.1 NZ_CP032761:c4508407-4507853 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT112206 NZ_CP032761:c4508407-4507853 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCATCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGACGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGATGGACGCGCGGTACGCCTGGTGGAAACCCTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V6AG16


Antitoxin

Source ID Structure

References