112204

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 197253..197758 Replicon chromosome
Accession NZ_CP032761
Organism Pseudomonas aeruginosa strain 268

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PA268_RS00915 Protein ID WP_003083773.1
Coordinates 197253..197534 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PA268_RS00920 Protein ID WP_003083775.1
Coordinates 197531..197758 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA268_RS00890 192504..193853 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PA268_RS00895 193902..194588 + 687 WP_003083762.1 FadR family transcriptional regulator -
PA268_RS00900 194689..195423 + 735 WP_003083764.1 GntR family transcriptional regulator -
PA268_RS00905 195627..196013 + 387 WP_003083767.1 aegerolysin family protein -
PA268_RS00910 196045..196953 - 909 WP_003083769.1 LysR family transcriptional regulator -
PA268_RS00915 197253..197534 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PA268_RS00920 197531..197758 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PA268_RS00925 197934..198554 - 621 WP_003101226.1 hypothetical protein -
PA268_RS00930 198655..199155 + 501 WP_003083778.1 LEA type 2 family protein -
PA268_RS00935 199228..199569 + 342 WP_014603467.1 alkylphosphonate utilization protein -
PA268_RS00940 199651..201078 - 1428 WP_003083784.1 GABA permease -
PA268_RS00945 201247..202740 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T112204 WP_003083773.1 NZ_CP032761:c197534-197253 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T112204 NZ_CP032761:c197534-197253 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT112204 WP_003083775.1 NZ_CP032761:c197758-197531 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT112204 NZ_CP032761:c197758-197531 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGATGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References