Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 2128070..2128695 | Replicon | chromosome |
| Accession | NZ_CP032760 | ||
| Organism | Halocella sp. SP3-1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | D7D81_RS10125 | Protein ID | WP_125989666.1 |
| Coordinates | 2128070..2128468 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | D7D81_RS10130 | Protein ID | WP_125989668.1 |
| Coordinates | 2128468..2128695 (-) | Length | 76 a.a. |
Genomic Context
Location: 2123832..2125145 (1314 bp)
Type: Others
Protein ID: WP_125989641.1
Type: Others
Protein ID: WP_125989641.1
Location: 2125353..2125580 (228 bp)
Type: Others
Protein ID: WP_125989627.1
Type: Others
Protein ID: WP_125989627.1
Location: 2125573..2126022 (450 bp)
Type: Others
Protein ID: WP_125989629.1
Type: Others
Protein ID: WP_125989629.1
Location: 2126621..2127916 (1296 bp)
Type: Others
Protein ID: WP_125989664.1
Type: Others
Protein ID: WP_125989664.1
Location: 2129076..2129714 (639 bp)
Type: Others
Protein ID: WP_205739165.1
Type: Others
Protein ID: WP_205739165.1
Location: 2129665..2130195 (531 bp)
Type: Others
Protein ID: WP_205739166.1
Type: Others
Protein ID: WP_205739166.1
Location: 2130748..2132724 (1977 bp)
Type: Others
Protein ID: WP_125989670.1
Type: Others
Protein ID: WP_125989670.1
Location: 2132935..2133468 (534 bp)
Type: Others
Protein ID: WP_164522207.1
Type: Others
Protein ID: WP_164522207.1
Location: 2128070..2128468 (399 bp)
Type: Toxin
Protein ID: WP_125989666.1
Type: Toxin
Protein ID: WP_125989666.1
Location: 2128468..2128695 (228 bp)
Type: Antitoxin
Protein ID: WP_125989668.1
Type: Antitoxin
Protein ID: WP_125989668.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D7D81_RS10105 | 2123832..2125145 | + | 1314 | WP_125989641.1 | group II intron reverse transcriptase/maturase | - |
| D7D81_RS10110 | 2125353..2125580 | + | 228 | WP_125989627.1 | UPF0175 family protein | - |
| D7D81_RS10115 | 2125573..2126022 | + | 450 | WP_125989629.1 | DUF3368 domain-containing protein | - |
| D7D81_RS10120 | 2126621..2127916 | + | 1296 | WP_125989664.1 | group II intron reverse transcriptase/maturase | - |
| D7D81_RS10125 | 2128070..2128468 | - | 399 | WP_125989666.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| D7D81_RS10130 | 2128468..2128695 | - | 228 | WP_125989668.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| D7D81_RS19850 | 2129076..2129714 | + | 639 | WP_205739165.1 | transposase | - |
| D7D81_RS19855 | 2129665..2130195 | + | 531 | WP_205739166.1 | transposase | - |
| D7D81_RS10140 | 2130748..2132724 | + | 1977 | WP_125989670.1 | hypothetical protein | - |
| D7D81_RS10145 | 2132935..2133468 | + | 534 | WP_164522207.1 | 2'-5' RNA ligase family protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | flmH | 2099254..2167492 | 68238 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14947.10 Da Isoelectric Point: 4.9505
>T112203 WP_125989666.1 NZ_CP032760:c2128468-2128070 [Halocella sp. SP3-1]
MKYMLDTNICIYIIKEKPEKVINKFHTLDVGDVCISSITLAELEYGVEKSQYTERNRLALAGFLSSIEVLPFSDKAASEY
GRIRAELERQGNIIGAYDLMIGAHALSENITLVTNNTKEFQRINNLSLENWA
MKYMLDTNICIYIIKEKPEKVINKFHTLDVGDVCISSITLAELEYGVEKSQYTERNRLALAGFLSSIEVLPFSDKAASEY
GRIRAELERQGNIIGAYDLMIGAHALSENITLVTNNTKEFQRINNLSLENWA
Download Length: 399 bp
>T112203 NZ_CP032760:c2128468-2128070 [Halocella sp. SP3-1]
ATGAAATATATGCTTGATACTAATATATGTATTTATATAATCAAAGAAAAGCCTGAAAAAGTTATAAACAAATTCCACAC
CTTAGATGTTGGTGATGTCTGCATTTCTTCCATTACTTTAGCTGAACTAGAATATGGTGTTGAAAAAAGTCAATACACAG
AACGAAATAGACTTGCGCTTGCCGGGTTTCTTTCCTCGATCGAGGTATTACCCTTTTCTGATAAAGCTGCTTCTGAATAT
GGTAGGATTAGAGCTGAATTAGAAAGGCAAGGCAATATAATAGGTGCGTATGATTTAATGATTGGAGCACATGCTCTGTC
TGAAAACATAACTCTTGTTACAAATAACACTAAAGAATTTCAGAGAATTAATAACTTGTCCCTCGAAAACTGGGCTTAA
ATGAAATATATGCTTGATACTAATATATGTATTTATATAATCAAAGAAAAGCCTGAAAAAGTTATAAACAAATTCCACAC
CTTAGATGTTGGTGATGTCTGCATTTCTTCCATTACTTTAGCTGAACTAGAATATGGTGTTGAAAAAAGTCAATACACAG
AACGAAATAGACTTGCGCTTGCCGGGTTTCTTTCCTCGATCGAGGTATTACCCTTTTCTGATAAAGCTGCTTCTGAATAT
GGTAGGATTAGAGCTGAATTAGAAAGGCAAGGCAATATAATAGGTGCGTATGATTTAATGATTGGAGCACATGCTCTGTC
TGAAAACATAACTCTTGTTACAAATAACACTAAAGAATTTCAGAGAATTAATAACTTGTCCCTCGAAAACTGGGCTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8900.04 Da Isoelectric Point: 6.3013
>AT112203 WP_125989668.1 NZ_CP032760:c2128695-2128468 [Halocella sp. SP3-1]
MDIAKLFKNGRSQAVRLPKEYRFNGSDVYVKKFEDIVLLIPKDSKWNSLETSLNYFSDDFLNDRNQPKIQDRDDL
MDIAKLFKNGRSQAVRLPKEYRFNGSDVYVKKFEDIVLLIPKDSKWNSLETSLNYFSDDFLNDRNQPKIQDRDDL
Download Length: 228 bp
>AT112203 NZ_CP032760:c2128695-2128468 [Halocella sp. SP3-1]
ATGGATATTGCAAAATTATTTAAAAATGGTAGAAGTCAAGCTGTCCGTCTTCCAAAAGAATATAGATTTAATGGTTCTGA
TGTTTATGTGAAAAAGTTTGAAGACATTGTTCTCCTTATTCCTAAAGATAGCAAATGGAATTCTTTAGAAACTAGTTTAA
ACTATTTTTCAGACGATTTTTTAAACGATCGTAATCAACCCAAAATACAGGATAGAGATGATTTGTAA
ATGGATATTGCAAAATTATTTAAAAATGGTAGAAGTCAAGCTGTCCGTCTTCCAAAAGAATATAGATTTAATGGTTCTGA
TGTTTATGTGAAAAAGTTTGAAGACATTGTTCTCCTTATTCCTAAAGATAGCAAATGGAATTCTTTAGAAACTAGTTTAA
ACTATTTTTCAGACGATTTTTTAAACGATCGTAATCAACCCAAAATACAGGATAGAGATGATTTGTAA