Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2128070..2128695 Replicon chromosome
Accession NZ_CP032760
Organism Halocella sp. SP3-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D7D81_RS10125 Protein ID WP_125989666.1
Coordinates 2128070..2128468 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D7D81_RS10130 Protein ID WP_125989668.1
Coordinates 2128468..2128695 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7D81_RS10105 2123832..2125145 + 1314 WP_125989641.1 group II intron reverse transcriptase/maturase -
D7D81_RS10110 2125353..2125580 + 228 WP_125989627.1 UPF0175 family protein -
D7D81_RS10115 2125573..2126022 + 450 WP_125989629.1 DUF3368 domain-containing protein -
D7D81_RS10120 2126621..2127916 + 1296 WP_125989664.1 group II intron reverse transcriptase/maturase -
D7D81_RS10125 2128070..2128468 - 399 WP_125989666.1 type II toxin-antitoxin system VapC family toxin Toxin
D7D81_RS10130 2128468..2128695 - 228 WP_125989668.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D7D81_RS19850 2129076..2129714 + 639 WP_205739165.1 transposase -
D7D81_RS19855 2129665..2130195 + 531 WP_205739166.1 transposase -
D7D81_RS10140 2130748..2132724 + 1977 WP_125989670.1 hypothetical protein -
D7D81_RS10145 2132935..2133468 + 534 WP_164522207.1 2'-5' RNA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - flmH 2099254..2167492 68238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(7-25)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14947.10 Da        Isoelectric Point: 4.9505

>T112203 WP_125989666.1 NZ_CP032760:c2128468-2128070 [Halocella sp. SP3-1]
MKYMLDTNICIYIIKEKPEKVINKFHTLDVGDVCISSITLAELEYGVEKSQYTERNRLALAGFLSSIEVLPFSDKAASEY
GRIRAELERQGNIIGAYDLMIGAHALSENITLVTNNTKEFQRINNLSLENWA

Download         Length: 399 bp

>T112203 NZ_CP032760:c2128468-2128070 [Halocella sp. SP3-1]
ATGAAATATATGCTTGATACTAATATATGTATTTATATAATCAAAGAAAAGCCTGAAAAAGTTATAAACAAATTCCACAC
CTTAGATGTTGGTGATGTCTGCATTTCTTCCATTACTTTAGCTGAACTAGAATATGGTGTTGAAAAAAGTCAATACACAG
AACGAAATAGACTTGCGCTTGCCGGGTTTCTTTCCTCGATCGAGGTATTACCCTTTTCTGATAAAGCTGCTTCTGAATAT
GGTAGGATTAGAGCTGAATTAGAAAGGCAAGGCAATATAATAGGTGCGTATGATTTAATGATTGGAGCACATGCTCTGTC
TGAAAACATAACTCTTGTTACAAATAACACTAAAGAATTTCAGAGAATTAATAACTTGTCCCTCGAAAACTGGGCTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8900.04 Da        Isoelectric Point: 6.3013

>AT112203 WP_125989668.1 NZ_CP032760:c2128695-2128468 [Halocella sp. SP3-1]
MDIAKLFKNGRSQAVRLPKEYRFNGSDVYVKKFEDIVLLIPKDSKWNSLETSLNYFSDDFLNDRNQPKIQDRDDL

Download         Length: 228 bp

>AT112203 NZ_CP032760:c2128695-2128468 [Halocella sp. SP3-1]
ATGGATATTGCAAAATTATTTAAAAATGGTAGAAGTCAAGCTGTCCGTCTTCCAAAAGAATATAGATTTAATGGTTCTGA
TGTTTATGTGAAAAAGTTTGAAGACATTGTTCTCCTTATTCCTAAAGATAGCAAATGGAATTCTTTAGAAACTAGTTTAA
ACTATTTTTCAGACGATTTTTTAAACGATCGTAATCAACCCAAAATACAGGATAGAGATGATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References