Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 5130468..5131104 Replicon chromosome
Accession NZ_CP032738
Organism Serratia sp. 1D1416

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D7I37_RS24905 Protein ID WP_129544820.1
Coordinates 5130468..5130884 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D7I37_RS24910 Protein ID WP_129544581.1
Coordinates 5130871..5131104 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7I37_RS24880 5125823..5126770 + 948 WP_129544576.1 TIGR03756 family integrating conjugative element protein -
D7I37_RS24885 5126778..5128169 + 1392 WP_129544577.1 integrating conjugative element protein -
D7I37_RS24890 5128166..5128525 + 360 WP_129544578.1 hypothetical protein -
D7I37_RS24895 5128536..5130053 + 1518 WP_129544579.1 conjugal transfer protein TraG N-terminal domain-containing protein -
D7I37_RS24900 5130067..5130438 - 372 WP_129544580.1 DUF3742 family protein -
D7I37_RS24905 5130468..5130884 - 417 WP_129544820.1 PIN domain-containing protein Toxin
D7I37_RS24910 5130871..5131104 - 234 WP_129544581.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D7I37_RS24915 5131224..5131834 - 611 Protein_4831 RES family NAD+ phosphorylase -
D7I37_RS24920 5131850..5132476 - 627 WP_129544582.1 integrase -
D7I37_RS24925 5132812..5134650 + 1839 WP_129544583.1 TraI domain-containing protein -
D7I37_RS27200 5134730..5134867 - 138 WP_207205545.1 glutaminase -
D7I37_RS24935 5135340..5135735 - 396 WP_129544584.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5061591..5165022 103431


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-120)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15331.62 Da        Isoelectric Point: 4.9045

>T112198 WP_129544820.1 NZ_CP032738:c5130884-5130468 [Serratia sp. 1D1416]
MSVAKTGAFLDSNVVLYLLSEDPVKADSAEALLKTRPVISVQVLNEVTSVCRRKLAMSWEDIGSFLELVRSFCDVVPLTV
EVHDRARQVALRHQLSFYDACIVAAATTAECLTLYSEDMNHGQILEDSLTIRNPFVRS

Download         Length: 417 bp

>T112198 NZ_CP032738:c5130884-5130468 [Serratia sp. 1D1416]
CTGAGCGTGGCTAAAACGGGTGCATTTCTGGACAGCAATGTTGTGCTTTACCTGTTATCTGAGGATCCGGTCAAGGCCGA
TAGCGCTGAAGCTCTGTTGAAGACGCGTCCTGTCATCAGCGTGCAGGTTCTCAATGAAGTGACCAGCGTATGCCGTCGTA
AACTCGCGATGAGCTGGGAAGATATCGGAAGTTTTCTGGAACTGGTCCGGAGTTTCTGTGATGTGGTGCCGCTGACGGTG
GAGGTTCATGACAGGGCTCGTCAGGTGGCACTGCGGCACCAGTTGTCTTTTTACGATGCCTGTATCGTCGCTGCCGCAAC
CACGGCTGAATGCCTGACCCTGTACAGTGAAGATATGAATCATGGACAGATTCTGGAAGACAGCCTCACCATCAGGAATC
CGTTCGTTCGTAGTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8825.03 Da        Isoelectric Point: 5.1851

>AT112198 WP_129544581.1 NZ_CP032738:c5131104-5130871 [Serratia sp. 1D1416]
MQVAKWGNSLAVRLPASLVEALELREGDDIEIIIDDPRTFAVRRKPGTEELLARLRNFRGKLPADFRFSREEDSERG

Download         Length: 234 bp

>AT112198 NZ_CP032738:c5131104-5130871 [Serratia sp. 1D1416]
ATGCAGGTTGCAAAATGGGGTAACAGTCTCGCGGTCAGACTGCCCGCCAGTCTGGTCGAGGCACTGGAACTCCGGGAGGG
TGACGATATCGAGATTATCATAGACGATCCGCGCACGTTTGCTGTCCGCAGAAAACCGGGTACTGAAGAGCTGCTGGCGC
GGTTGCGTAATTTCCGCGGTAAGCTCCCGGCCGATTTCAGGTTCAGCCGTGAAGAGGACTCTGAGCGTGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References