Detailed information of TA system TA112197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4809587..4810218
• Replicon: chromosome
• Accession: NZ_CP032738
• Organism: Serratia sp. 1D1416

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D7I37_RS23345
• Protein ID: WP_019452963.1
• Coordinates: 4809587..4809985 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A240C5I5
• Locus tag: D7I37_RS23350
• Protein ID: WP_061794711.1
• Coordinates: 4809985..4810218 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D7I37_RS23320	4805156..4805530	+	375	WP_095098030.1	type II toxin-antitoxin system RelE/ParE family toxin	-
D7I37_RS23325	4805523..4805825	+	303	WP_061794706.1	DNA-binding transcriptional regulator	-
D7I37_RS23330	4805835..4806239	-	405	WP_061794707.1	flagellar protein FlhE	-
D7I37_RS23335	4806239..4808317	-	2079	WP_129544450.1	flagellar biosynthesis protein FlhA	-
D7I37_RS23340	4808310..4809461	-	1152	WP_129544451.1	flagellar type III secretion system protein FlhB	-
D7I37_RS23345	4809587..4809985	-	399	WP_019452963.1	type II toxin-antitoxin system VapC family toxin	Toxin
D7I37_RS23350	4809985..4810218	-	234	WP_061794711.1	antitoxin	Antitoxin
D7I37_RS23355	4810345..4810989	-	645	WP_061794712.1	protein phosphatase CheZ	-
D7I37_RS23360	4811000..4811389	-	390	WP_006326141.1	chemotaxis response regulator CheY	-
D7I37_RS23365	4811493..4812542	-	1050	WP_061794713.1	chemotaxis response regulator protein-glutamate methylesterase	-
D7I37_RS23370	4812542..4813414	-	873	WP_061794714.1	protein-glutamate O-methyltransferase CheR	-
D7I37_RS23375	4813443..4815068	-	1626	WP_129544452.1	Tar ligand binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	fliZ / fliA / fliS / fliE / fliF / fliG / fliH / fliI / fliJ / fliL / fliM / fliN / fliP / fliQ / fliR / flgL / flgK / flgJ / flgI / flgH / flgG / flgF / flgE / flgC / flgB / flhA / flhB / cheZ / cheY / cheB / cheR / cheD / cheW / cheA / motB / motA / flhC / flhD / hsiB1/vipA / hsiC1/vipB / clpV1 / mgtB	4743698..4968222	224524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14876.02 Da
• Isoelectric Point: 8.4955

>T112197 WP_019452963.1 NZ_CP032738:c4809985-4809587 [Serratia sp. 1D1416]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSVTYGELVHGVEKSSRPAVNARVVEDFVSRLDILDYGAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVDGLRLENWL

Nucleotide

• Length: 399 bp

>T112197 NZ_CP032738:c4809985-4809587 [Serratia sp. 1D1416]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCTCTGGAAGTGCTGGAGGCGTTCAA
TCGCTATGCGGGCAAAATGGTCATTTCGTCGGTCACCTATGGCGAATTGGTTCACGGAGTGGAGAAAAGCTCGCGTCCGG
CGGTTAACGCGAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACGGCGCCAAAGCGGCTTCGCACTAC
GGCAACATTCGGGCTGCGCTGGAGCGTCAGGGAACGCCTATTGGCGTAAACGATCTGCATATCGCTGGGCATGCGCGCAG
CGAAGGATTGATTCTGGTGACCAATAACCGACGCGAATTTGAGCGCGTTGATGGCTTACGGCTGGAAAATTGGCTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8915.93 Da
• Isoelectric Point: 4.7954

>AT112197 WP_061794711.1 NZ_CP032738:c4810218-4809985 [Serratia sp. 1D1416]
MTLGSVFTNNRTQAVRLPTEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREEF

Nucleotide

• Length: 234 bp

>AT112197 NZ_CP032738:c4810218-4809985 [Serratia sp. 1D1416]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTACAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCTCTGGAGAATACCTGGGACAGTTTCTTCTGCG
CGGAAAATGAGGTGAGCGATGACTTCCTCAATGAACGCGCCGGGCAACACCAGCGCGAGCGGGAAGAGTTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A240C5I5