Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2635234..2635857 Replicon chromosome
Accession NZ_CP032738
Organism Serratia sp. 1D1416

Toxin (Protein)


Gene name Hha Uniprot ID A0A240BII5
Locus tag D7I37_RS12500 Protein ID WP_061796337.1
Coordinates 2635234..2635437 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag D7I37_RS12505 Protein ID WP_004940312.1
Coordinates 2635489..2635857 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7I37_RS12475 2630255..2630569 - 315 WP_061796310.1 MGMT family protein -
D7I37_RS12485 2630926..2632269 - 1344 WP_129543739.1 NCS2 family permease -
D7I37_RS12490 2632295..2634088 - 1794 WP_129543740.1 adenine deaminase -
D7I37_RS12495 2634225..2635154 + 930 WP_061796335.1 LysR family transcriptional regulator -
D7I37_RS12500 2635234..2635437 - 204 WP_061796337.1 hemolysin expression modulator Hha Toxin
D7I37_RS12505 2635489..2635857 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
D7I37_RS12510 2636017..2636370 - 354 WP_061796339.1 hypothetical protein -
D7I37_RS27025 2636654..2636800 + 147 WP_165283095.1 hypothetical protein -
D7I37_RS12515 2636797..2637510 + 714 WP_129543741.1 ABC transporter ATP-binding protein -
D7I37_RS12520 2637507..2638364 + 858 WP_061796344.1 metal ABC transporter permease -
D7I37_RS12525 2638390..2639268 + 879 WP_061796346.1 metal ABC transporter substrate-binding protein -
D7I37_RS12530 2639377..2639517 - 141 WP_073970263.1 type B 50S ribosomal protein L36 -
D7I37_RS12535 2639527..2639787 - 261 WP_095096066.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.42 Da        Isoelectric Point: 6.9756

>T112188 WP_061796337.1 NZ_CP032738:c2635437-2635234 [Serratia sp. 1D1416]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTAVWKYVR

Download         Length: 204 bp

>T112188 NZ_CP032738:c2635437-2635234 [Serratia sp. 1D1416]
ATGACAAAAATCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACGCTTGAACGTGTTATTGAGAAAAATAA
GTATGAACTTTCCGATGATGAGCTGGAGCTGTTTTACTCCGCCGCCGATCACCGCCTGGCAGAGCTCACCATGAACAAAC
TGTACGATAAAATCCCCACCGCCGTTTGGAAGTATGTACGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT112188 WP_004940312.1 NZ_CP032738:c2635857-2635489 [Serratia sp. 1D1416]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT112188 NZ_CP032738:c2635857-2635489 [Serratia sp. 1D1416]
ATGGATGAGTATTCGCCTAAGCGGCATGATATTGCTCAACTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATCGC
AACCCTGGGAGACAGCCACCACGGTTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGATCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGTTGTTTAGCAGCTACGGTATCAATGACTCCGACCTTCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A240BII5

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References