Detailed information of TA system TA112187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1162517..1163256
• Replicon: chromosome
• Accession: NZ_CP032738
• Organism: Serratia sp. 1D1416

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D7I37_RS05670
• Protein ID: WP_061798973.1
• Coordinates: 1162777..1163256 (+)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A240CCP7
• Locus tag: D7I37_RS05665
• Protein ID: WP_061798971.1
• Coordinates: 1162517..1162780 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D7I37_RS05645	1158587..1159267	+	681	WP_129543432.1	GMP/IMP nucleotidase	-
D7I37_RS05650	1159264..1159671	+	408	WP_061798964.1	ribosome-associated heat shock protein Hsp15	-
D7I37_RS05655	1159697..1160575	+	879	WP_061798966.1	Hsp33 family molecular chaperone HslO	-
D7I37_RS05660	1160772..1162391	+	1620	WP_095099672.1	phosphoenolpyruvate carboxykinase (ATP)	-
D7I37_RS05665	1162517..1162780	+	264	WP_061798971.1	hypothetical protein	Antitoxin
D7I37_RS05670	1162777..1163256	+	480	WP_061798973.1	type II toxin-antitoxin system VapC family toxin	Toxin
D7I37_RS05675	1163279..1164649	-	1371	WP_061798975.1	two-component system sensor histidine kinase EnvZ	-
D7I37_RS05680	1164646..1165365	-	720	WP_004709363.1	two-component system response regulator OmpR	-
D7I37_RS05685	1165676..1165990	-	315	WP_061798977.1	chaperone-modulator protein CbpM	-
D7I37_RS05690	1165993..1166943	-	951	WP_061798979.1	curved DNA-binding protein	-
D7I37_RS05695	1167174..1167647	+	474	WP_061798982.1	transcription elongation factor GreB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17866.58 Da
• Isoelectric Point: 6.4742

>T112187 WP_061798973.1 NZ_CP032738:1162777-1163256 [Serratia sp. 1D1416]
MIILDTNVMSETLRPSPHYNVINWLNEKDNDELYLSAIVIAELFNGAACMPDGKRQRDLKLKLADAIQLKFEGQILPFDG
LCAMQYAELTARNRLQGKLMSVPDAQIAATCLHYGAALATRNSKNFLHCGIELIDPWQAPAGRRLHEDAAEYYVMSRKS

Nucleotide

• Length: 480 bp

>T112187 NZ_CP032738:1162777-1163256 [Serratia sp. 1D1416]
ATGATTATTCTCGACACCAACGTCATGTCAGAAACGCTGCGCCCCAGCCCACACTACAACGTCATAAACTGGTTAAACGA
AAAGGACAATGACGAGCTCTACCTGAGCGCCATTGTCATTGCCGAGCTGTTCAACGGCGCCGCCTGCATGCCTGACGGCA
AGCGTCAGCGGGATCTGAAGCTCAAATTGGCGGACGCCATCCAGCTGAAGTTCGAAGGGCAAATTCTGCCGTTTGACGGG
CTGTGCGCGATGCAATACGCGGAGTTGACGGCAAGAAACCGGCTGCAGGGCAAGCTGATGAGCGTACCGGATGCCCAAAT
CGCCGCCACCTGCCTGCACTACGGCGCCGCCCTGGCCACCCGCAACAGCAAAAACTTTCTCCACTGCGGCATCGAGTTAA
TCGATCCCTGGCAGGCGCCGGCCGGCCGTCGGCTGCATGAGGATGCGGCGGAATACTACGTGATGAGCAGGAAGTCCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9813.12 Da
• Isoelectric Point: 4.8500

>AT112187 WP_061798971.1 NZ_CP032738:1162517-1162780 [Serratia sp. 1D1416]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARTILKQALVKKPPRYGLGTWMHQHFAEFGGVELDIPPRDAVPPRIVSF
DDEDDNA

Nucleotide

• Length: 264 bp

>AT112187 NZ_CP032738:1162517-1162780 [Serratia sp. 1D1416]
ATGGCTACTATAACCGTCAGGAATCTGGACGATGAGATAAAAGAGCTGCTGCGCATTTCGGCAGCGAAAAATGGCCATTC
GATGGAAGAGGAAGCGCGCACGATCCTGAAACAGGCGCTGGTGAAAAAGCCACCGCGCTACGGGTTGGGTACCTGGATGC
ATCAGCACTTCGCCGAATTTGGCGGCGTCGAGCTGGACATTCCGCCGCGAGACGCCGTGCCGCCTCGCATAGTCAGCTTT
GATGATGAAGATGACAACGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A240CCP7