Detailed information of TA system TA112185

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 551490..552159
• Replicon: chromosome
• Accession: NZ_CP032738
• Organism: Serratia sp. 1D1416

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: D7I37_RS02650
• Protein ID: WP_061796944.1
• Coordinates: 551490..551912 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A240CA43
• Locus tag: D7I37_RS02655
• Protein ID: WP_061796946.1
• Coordinates: 551893..552159 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D7I37_RS02630	547386..547904	+	519	WP_061796935.1	flavodoxin FldB	-
D7I37_RS02635	547942..549299	-	1358	Protein_502	cell envelope integrity protein CreD	-
D7I37_RS02640	549380..550798	-	1419	WP_095099103.1	two-component system sensor histidine kinase CreC	-
D7I37_RS02645	550795..551490	-	696	WP_061796942.1	two-component system response regulator CreB	-
D7I37_RS02650	551490..551912	-	423	WP_061796944.1	protein YgfX	Toxin
D7I37_RS02655	551893..552159	-	267	WP_061796946.1	FAD assembly factor SdhE	Antitoxin
D7I37_RS02660	552483..553475	+	993	WP_061796947.1	tRNA-modifying protein YgfZ	-
D7I37_RS02665	553511..553678	-	168	Protein_508	DUF2165 family protein	-
D7I37_RS02670	553704..554378	-	675	WP_061796950.1	hemolysin III family protein	-
D7I37_RS02675	554562..555170	+	609	WP_061796951.1	HD domain-containing protein	-
D7I37_RS02680	555210..556531	-	1322	Protein_511	MHS family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16428.44 Da
• Isoelectric Point: 10.8423

>T112185 WP_061796944.1 NZ_CP032738:c551912-551490 [Serratia sp. 1D1416]
VAQWRCDVRISWRTQLFSLLTHGILILLILISPWPEGYGPIWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMLGYGMLLTLQPLAGKKRRRLWLASDSMGKEEWRHLRQLLLYPPAGDDEDA

Nucleotide

• Length: 423 bp

>T112185 NZ_CP032738:c551912-551490 [Serratia sp. 1D1416]
GTGGCCCAGTGGCGATGTGACGTCCGCATTTCCTGGCGCACCCAGTTATTTTCGCTGCTGACGCACGGCATTCTGATACT
GCTGATCCTGATTTCGCCATGGCCGGAAGGCTACGGGCCGATCTGGCTGGTGCTGTTGACGCTGGTGGTGTTTCAATGCA
TCCGCAGCCAGAAGCGCATCGCCGCGGCGCAGGGAGAACTGCGCCTGCTGGCGGACCGGCGTTTCAGCTGGCACGGCCGC
GAATGGCGGTTGGCGAAAAAGCCCTGGATGCTCGGCTACGGCATGCTGCTGACGCTGCAGCCGCTGGCGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCCTCGGACAGCATGGGTAAGGAAGAGTGGCGGCATCTGCGCCAGCTGTTGCTGTATCCGCCGG
CCGGCGATGACGAGGACGCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10488.99 Da
• Isoelectric Point: 4.7921

>AT112185 WP_061796946.1 NZ_CP032738:c552159-551893 [Serratia sp. 1D1416]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDQLNDTDKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT112185 NZ_CP032738:c552159-551893 [Serratia sp. 1D1416]
ATGGATATTAATAACAAAGCACGTATTCACTGGGCCTGCCGCCGCGGCATGCGCGAGTTGGACATCTCCATCATGCCGTT
CTTCGAATACGAGTACGACCAGCTGAATGATACCGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A240CA43