Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 52766..53328 Replicon chromosome
Accession NZ_CP032738
Organism Serratia sp. 1D1416

Toxin (Protein)


Gene name doc Uniprot ID A0A240C794
Locus tag D7I37_RS00300 Protein ID WP_061799378.1
Coordinates 52766..53122 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A240C7D1
Locus tag D7I37_RS00305 Protein ID WP_061799380.1
Coordinates 53119..53328 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7I37_RS00275 47996..48916 + 921 WP_129543130.1 oxygen-dependent coproporphyrinogen oxidase -
D7I37_RS00280 48916..49371 + 456 WP_061799412.1 YaiI/YqxD family protein -
D7I37_RS00285 49390..50229 - 840 WP_129543131.1 ChaN family lipoprotein -
D7I37_RS00290 50423..51832 + 1410 WP_095098639.1 S-methylmethionine permease -
D7I37_RS00295 51822..52760 + 939 WP_061799377.1 homocysteine S-methyltransferase -
D7I37_RS00300 52766..53122 - 357 WP_061799378.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
D7I37_RS00305 53119..53328 - 210 WP_061799380.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D7I37_RS00310 53426..55705 - 2280 WP_061799382.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
D7I37_RS00315 55891..56064 - 174 WP_165283073.1 hypothetical protein -
D7I37_RS00320 56045..56425 - 381 WP_061799384.1 DUF2570 family protein -
D7I37_RS00325 56422..56823 - 402 WP_129543133.1 M15 family metallopeptidase -
D7I37_RS00330 56813..57139 - 327 WP_061799391.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(20-108)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13032.87 Da        Isoelectric Point: 5.1312

>T112183 WP_061799378.1 NZ_CP032738:c53122-52766 [Serratia sp. 1D1416]
MIFLTAEDIAEFNAEIVPQGRQDGSKVEAVANRVLNAYHYDNVSDIYHLAAIYLIAISQGHIFLDGNKRTAFQSMALFLG
INGIALREDAKLVELTVEAAKGRLNAVETAKQLRQLTE

Download         Length: 357 bp

>T112183 NZ_CP032738:c53122-52766 [Serratia sp. 1D1416]
ATGATTTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATTGTGCCTCAAGGGCGCCAGGATGGCAGCAAGGT
TGAGGCCGTGGCCAATAGAGTGCTTAATGCCTACCATTATGACAACGTCTCGGATATCTATCATCTCGCCGCTATCTATC
TGATAGCTATCAGCCAGGGGCATATCTTCCTCGATGGCAATAAACGAACGGCTTTTCAGAGCATGGCGCTGTTTCTCGGC
ATCAATGGCATCGCATTACGGGAAGATGCGAAATTGGTCGAGTTAACGGTTGAGGCGGCGAAAGGCCGCCTCAATGCTGT
AGAAACTGCAAAGCAGTTGCGCCAGTTAACTGAATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7829.87 Da        Isoelectric Point: 8.5262

>AT112183 WP_061799380.1 NZ_CP032738:c53328-53119 [Serratia sp. 1D1416]
MTTISYTSARNNLAEVFQEAQNQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQLKHADTINALADR

Download         Length: 210 bp

>AT112183 NZ_CP032738:c53328-53119 [Serratia sp. 1D1416]
ATGACGACAATCAGCTATACCTCGGCGAGAAATAACTTGGCTGAGGTTTTTCAGGAAGCGCAAAATCAACCGGTCGAAGT
CACCCGCCGCGGCCACGACGAGGTCTATATCATCAGCAAGGCAGACTATGAGGTATTGGTTAAAGCCAAAGTGAAAGCGC
GTATTCAGCTCAAACATGCAGATACCATTAATGCATTGGCGGATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A240C794

Antitoxin

Source ID Structure
AlphaFold DB A0A240C7D1

References