Detailed information of TA system TA112182

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 1413538..1414208
• Replicon: chromosome
• Accession: NZ_CP032707
• Organism: Brevundimonas naejangsanensis strain BRV3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D8I30_RS06625
• Protein ID: WP_121482039.1
• Coordinates: 1413538..1413957 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D8I30_RS06630
• Protein ID: WP_121482040.1
• Coordinates: 1413957..1414208 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8I30_RS06610	1408907..1409845	+	939	WP_121482036.1	pirin family protein	-
D8I30_RS06615	1409855..1410586	-	732	WP_121482037.1	ligase-associated DNA damage response endonuclease PdeM	-
D8I30_RS06620	1410753..1413383	-	2631	WP_121482038.1	ligase-associated DNA damage response DEXH box helicase	-
D8I30_RS14385	1413380..1413517	-	138	WP_162938824.1	hypothetical protein	-
D8I30_RS06625	1413538..1413957	-	420	WP_121482039.1	type II toxin-antitoxin system VapC family toxin	Toxin
D8I30_RS06630	1413957..1414208	-	252	WP_121482040.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D8I30_RS06635	1414316..1417162	+	2847	WP_121482041.1	ATP-dependent DNA helicase	-
D8I30_RS06640	1417406..1417879	+	474	WP_121482042.1	Cys-tRNA(Pro) deacylase	-
D8I30_RS06645	1418100..1419158	+	1059	WP_121482043.1	DUF2125 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-67)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15638.80 Da
• Isoelectric Point: 4.9890

>T112182 WP_121482039.1 NZ_CP032707:c1413957-1413538 [Brevundimonas naejangsanensis]
MFLLDTNAISEPKRARPDAGLIGWLSDQLLSDLHLSVITVGELRRGIVRLEPGRRRDDLDYWLSDLVLRFDDRILPVDLD
VTERWASLAEAARTAGRASDMTDELIAATAHVHGLAVVTRNVRHFEPLGCRVLSPWSEE

Nucleotide

• Length: 420 bp

>T112182 NZ_CP032707:c1413957-1413538 [Brevundimonas naejangsanensis]
ATGTTTCTGCTCGACACCAACGCCATCAGCGAGCCGAAGCGCGCGCGACCGGACGCGGGCCTGATCGGCTGGCTCAGCGA
TCAGCTGCTGTCGGACCTGCACCTCAGCGTCATCACGGTGGGGGAGCTTCGGCGCGGCATCGTCCGCCTCGAACCCGGCC
GCCGACGCGACGATCTCGACTATTGGCTTAGCGACCTGGTGCTGAGGTTCGATGACCGGATTCTGCCGGTCGATCTGGAC
GTCACCGAGCGCTGGGCCTCTCTAGCAGAGGCCGCGCGAACGGCGGGTCGAGCCTCGGACATGACGGACGAACTGATCGC
GGCGACCGCTCATGTCCATGGCCTGGCGGTGGTAACCCGCAACGTCCGGCATTTCGAGCCTCTGGGCTGCCGGGTGCTCT
CGCCATGGAGCGAAGAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9394.51 Da
• Isoelectric Point: 5.7235

>AT112182 WP_121482040.1 NZ_CP032707:c1414208-1413957 [Brevundimonas naejangsanensis]
MSWSVAKAKDNLSEVIRRSRSEGPQEISLHGEAAAVVLSAEDFRRLKDPRAAHDFKDWLLNGPSLEGVDLERDRRPTRDI
DPL

Nucleotide

• Length: 252 bp

>AT112182 NZ_CP032707:c1414208-1413957 [Brevundimonas naejangsanensis]
ATGAGCTGGAGCGTCGCCAAGGCGAAGGACAATCTCTCGGAGGTCATCCGACGTTCGCGCAGCGAGGGGCCGCAGGAGAT
TTCCCTGCACGGAGAGGCCGCCGCCGTCGTGTTGTCGGCTGAGGACTTCCGCCGGTTGAAAGACCCTCGCGCGGCCCATG
ATTTCAAGGACTGGCTGCTGAACGGTCCGTCGCTGGAAGGCGTCGATCTGGAGCGAGATCGCCGTCCGACGCGGGACATC
GACCCGCTCTGA