Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1026195..1026815 Replicon chromosome
Accession NZ_CP032702
Organism Pantoea dispersa strain DSM 32899

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag D8B20_RS04665 Protein ID WP_145887586.1
Coordinates 1026195..1026413 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag D8B20_RS04670 Protein ID WP_145887588.1
Coordinates 1026438..1026815 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8B20_RS04635 1022009..1022347 + 339 WP_003850469.1 P-II family nitrogen regulator -
D8B20_RS04640 1022381..1023670 + 1290 WP_145887578.1 ammonium transporter AmtB -
D8B20_RS04645 1023732..1024595 - 864 WP_145887580.1 acyl-CoA thioesterase II -
D8B20_RS04650 1024798..1025355 + 558 WP_145887582.1 YbaY family lipoprotein -
D8B20_RS04655 1025480..1025797 - 318 WP_145887584.1 MGMT family protein -
D8B20_RS04665 1026195..1026413 - 219 WP_145887586.1 hemolysin expression modulator Hha Toxin
D8B20_RS04670 1026438..1026815 - 378 WP_145887588.1 Hha toxicity modulator TomB Antitoxin
D8B20_RS04675 1026961..1027314 - 354 WP_145887590.1 hypothetical protein -
D8B20_RS04680 1027654..1028310 + 657 WP_145887592.1 ATP-binding cassette domain-containing protein -
D8B20_RS04685 1028307..1029143 + 837 WP_145887593.1 metal ABC transporter permease -
D8B20_RS04690 1029167..1030048 + 882 WP_145887595.1 metal ABC transporter substrate-binding protein -
D8B20_RS04695 1030091..1030231 - 141 WP_010616859.1 type B 50S ribosomal protein L36 -
D8B20_RS04700 1030249..1030506 - 258 WP_145887597.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8586.87 Da        Isoelectric Point: 8.8662

>T112177 WP_145887586.1 NZ_CP032702:c1026413-1026195 [Pantoea dispersa]
MNNQALTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPGSVWKYVR

Download         Length: 219 bp

>T112177 NZ_CP032702:c1026413-1026195 [Pantoea dispersa]
ATGAACAACCAAGCCCTGACAAAAACTGACTATTTAATGCGACTGCGCCGCTGTCGCTCGATTGATACCCTTGAACGGGT
GATTGAAAAAAATAAGTATGAATTATCTGACGACGAGTTAGCGGTGTTCTATTCCGCAGCCGATCACCGTCTGGCGGAGC
TGACCATGAATAAGCTCTATGACAAAGTGCCCGGTTCTGTCTGGAAATACGTCCGCTAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14605.24 Da        Isoelectric Point: 4.4796

>AT112177 WP_145887588.1 NZ_CP032702:c1026815-1026438 [Pantoea dispersa]
MDEYSPKRHDIAQLKFLCENLSDESMATLTDSHHGWVNDPTSPGNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSSYGINTQDLQRWQRSAKRLFNLFAEECAYLQQPSHSF

Download         Length: 378 bp

>AT112177 NZ_CP032702:c1026815-1026438 [Pantoea dispersa]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATTTCTGTGTGAGAACCTGTCTGACGAGAGTATGGC
GACATTAACAGACAGCCACCACGGCTGGGTTAATGACCCGACATCTCCAGGCAATTTACAGCTCAACGATTTAATTGAGC
ATATCGCCTCTTTCACAATGAATTACAAAATTAAGCATGTTGAAGATGAAGCGCTGATTACGCAAATTGATGAATATCTT
GATGATACCTTTATGCTGTTCAGCAGTTATGGCATCAATACTCAGGATCTTCAGCGCTGGCAACGTTCAGCCAAACGCTT
ATTTAATCTGTTTGCCGAAGAGTGCGCTTATCTCCAGCAACCCAGCCATTCCTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References