Detailed information of TA system TA112176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1588450..1589062
• Replicon: chromosome
• Accession: NZ_CP032700
• Organism: Streptococcus pyogenes strain TSPY556

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D8S77_RS08100
• Protein ID: WP_002994716.1
• Coordinates: 1588727..1589062 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: D8S77_RS08095
• Protein ID: WP_002988079.1
• Coordinates: 1588450..1588737 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8S77_RS08070	1583641..1584624	-	984	WP_111702287.1	tagatose-bisphosphate aldolase	-
D8S77_RS08075	1584628..1585557	-	930	WP_115354284.1	tagatose-6-phosphate kinase	-
D8S77_RS08080	1585603..1586118	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
D8S77_RS08085	1586153..1586581	-	429	WP_002991702.1	galactose-6-phosphate isomerase subunit LacA	-
D8S77_RS08090	1587027..1587800	+	774	WP_023605292.1	DeoR/GlpR family DNA-binding transcription regulator	-
D8S77_RS08095	1588450..1588737	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
D8S77_RS08100	1588727..1589062	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D8S77_RS09375	1589213..1589650	+	438	Protein_1487	integrase	-
D8S77_RS08110	1589798..1590196	+	399	WP_181879099.1	tyrosine-type recombinase/integrase	-
D8S77_RS08115	1590316..1590708	-	393	WP_002982716.1	30S ribosomal protein S9	-
D8S77_RS08120	1590729..1591175	-	447	WP_002982710.1	50S ribosomal protein L13	-
D8S77_RS08125	1591393..1591599	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
D8S77_RS08130	1591596..1592294	-	699	WP_021340943.1	hypothetical protein	-
D8S77_RS08135	1592430..1593290	-	861	WP_085634396.1	DegV family protein	-
D8S77_RS08140	1593387..1593905	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T112176 WP_002994716.1 NZ_CP032700:1588727-1589062 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T112176 NZ_CP032700:1588727-1589062 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT112176 WP_002988079.1 NZ_CP032700:1588450-1588737 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT112176 NZ_CP032700:1588450-1588737 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94