Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1648047..1648659 Replicon chromosome
Accession NZ_CP032699
Organism Streptococcus pyogenes strain TSPY155

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag D8S76_RS08440 Protein ID WP_011018227.1
Coordinates 1648324..1648659 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag D8S76_RS08435 Protein ID WP_002988079.1
Coordinates 1648047..1648334 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8S76_RS08405 1643225..1644208 - 984 WP_011285168.1 tagatose-bisphosphate aldolase -
D8S76_RS08410 1644212..1645141 - 930 WP_115224651.1 tagatose-6-phosphate kinase -
D8S76_RS08415 1645189..1645704 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
D8S76_RS08420 1645739..1646167 - 429 WP_023078895.1 galactose-6-phosphate isomerase subunit LacA -
D8S76_RS08425 1646613..1647386 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
D8S76_RS08435 1648047..1648334 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
D8S76_RS08440 1648324..1648659 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D8S76_RS09625 1648811..1649281 + 471 Protein_1552 integrase -
D8S76_RS09630 1649614..1649763 + 150 WP_011285175.1 integrase -
D8S76_RS08455 1649883..1650275 - 393 WP_002982716.1 30S ribosomal protein S9 -
D8S76_RS08460 1650296..1650742 - 447 WP_002982710.1 50S ribosomal protein L13 -
D8S76_RS08465 1650960..1651166 - 207 WP_023078893.1 helix-turn-helix transcriptional regulator -
D8S76_RS08470 1651163..1651861 - 699 WP_023078900.1 hypothetical protein -
D8S76_RS08475 1651997..1652857 - 861 WP_011529009.1 DegV family protein -
D8S76_RS08480 1652954..1653472 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T112174 WP_011018227.1 NZ_CP032699:1648324-1648659 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T112174 NZ_CP032699:1648324-1648659 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT112174 WP_002988079.1 NZ_CP032699:1648047-1648334 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT112174 NZ_CP032699:1648047-1648334 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References