Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 253926..254566 Replicon plasmid pRCCGE525c
Accession NZ_CP032695
Organism Rhizobium jaguaris strain CCGE525

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CCGE525_RS23245 Protein ID WP_120706733.1
Coordinates 253926..254312 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID K0PZZ6
Locus tag CCGE525_RS23250 Protein ID WP_007538500.1
Coordinates 254312..254566 (-) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCGE525_RS23225 249230..250465 - 1236 WP_120706729.1 ABC transporter substrate-binding protein -
CCGE525_RS23230 250525..251478 - 954 WP_120706730.1 sugar phosphate isomerase/epimerase -
CCGE525_RS23235 251699..252790 + 1092 WP_120706731.1 LacI family transcriptional regulator -
CCGE525_RS23240 252859..253929 - 1071 WP_120706732.1 site-specific integrase -
CCGE525_RS23245 253926..254312 - 387 WP_120706733.1 type II toxin-antitoxin system VapC family toxin Toxin
CCGE525_RS23250 254312..254566 - 255 WP_007538500.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CCGE525_RS23255 254828..255763 + 936 WP_120706734.1 DUF1403 family protein -
CCGE525_RS23260 255765..256439 + 675 WP_120706735.1 SMC-Scp complex subunit ScpB -
CCGE525_RS23265 256519..257730 - 1212 WP_120706736.1 Na+/H+ antiporter NhaA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - tssC-5 / katA 1..2584926 2584926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-125)

Antitoxin

(1-83)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14005.77 Da        Isoelectric Point: 4.5935

>T112164 WP_120706733.1 NZ_CP032695:c254312-253926 [Rhizobium jaguaris]
MVIDTSAIVAIFFNEPDALYYSERIADDPIRLISAATLVEAAMVIEGRFGEAGGAELDLWLHKTNLEAVAVTSEHADQAR
RAWRRYGKGRHPAGLNYGDCFSYALAALTGEPLLFKGNDFKQTDVEAA

Download         Length: 387 bp

>T112164 NZ_CP032695:c254312-253926 [Rhizobium jaguaris]
ATGGTGATCGATACGTCAGCGATCGTCGCGATCTTTTTCAATGAACCGGATGCCCTCTACTACAGCGAACGCATTGCCGA
CGATCCCATCCGGCTGATTTCGGCGGCAACGCTCGTCGAAGCCGCGATGGTCATCGAGGGGCGCTTCGGCGAGGCAGGCG
GAGCAGAACTCGATCTCTGGTTGCACAAGACCAATCTGGAGGCCGTTGCGGTGACCTCCGAGCATGCCGACCAGGCCCGC
CGGGCCTGGCGCCGCTACGGCAAGGGTCGCCATCCTGCCGGCCTGAATTACGGCGACTGCTTCTCCTATGCCCTCGCCGC
GCTGACCGGCGAGCCGCTGCTCTTCAAGGGGAACGACTTCAAACAGACAGATGTCGAGGCGGCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9336.73 Da        Isoelectric Point: 6.3656

>AT112164 WP_007538500.1 NZ_CP032695:c254566-254312 [Rhizobium jaguaris]
MALSIKDPETEKLARALAARTGETITIATRRALEERLKRMGSQAKKAALLDDMEAMRRRLSALPVLDDRSPDEIIGYDEN
GIPN

Download         Length: 255 bp

>AT112164 NZ_CP032695:c254566-254312 [Rhizobium jaguaris]
ATGGCGCTGAGCATCAAAGACCCCGAGACGGAGAAGCTCGCGCGCGCACTCGCTGCGCGCACCGGCGAAACCATCACCAT
CGCGACGCGGCGCGCGCTGGAAGAGCGCCTCAAGCGTATGGGATCGCAAGCGAAGAAGGCTGCCCTCCTCGACGACATGG
AGGCGATGCGGCGACGCTTGAGCGCTCTGCCGGTTCTCGATGATCGCAGTCCGGATGAAATCATCGGTTACGACGAAAAC
GGTATTCCGAACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB K0PZZ6

References