Detailed information of TA system TA112089

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 3601643..3602595
• Replicon: chromosome
• Accession: NZ_CP032675
• Organism: Rhodococcus rhodochrous strain ATCC BAA870

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: D1O33_RS16425
• Protein ID: WP_159418169.1
• Coordinates: 3602026..3602595 (+)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: D1O33_RS16420
• Protein ID: WP_120282896.1
• Coordinates: 3601643..3602029 (+)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1O33_RS16405	3597621..3598553	+	933	WP_159418167.1	TAXI family TRAP transporter solute-binding subunit	-
D1O33_RS16410	3599932..3600297	-	366	WP_120282900.1	HNH endonuclease	-
D1O33_RS16415	3600367..3601437	-	1071	WP_159418168.1	class I SAM-dependent methyltransferase	-
D1O33_RS16420	3601643..3602029	+	387	WP_120282896.1	hypothetical protein	Antitoxin
D1O33_RS16425	3602026..3602595	+	570	WP_159418169.1	zeta toxin family protein	Toxin
D1O33_RS16430	3602627..3604351	-	1725	WP_159418170.1	CocE/NonD family hydrolase	-
D1O33_RS16435	3604377..3605315	-	939	WP_120282890.1	MBL fold metallo-hydrolase	-
D1O33_RS16440	3605308..3606255	-	948	WP_159418171.1	alpha/beta hydrolase	-
D1O33_RS16445	3606299..3607414	-	1116	WP_159418172.1	FAD-dependent monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-67)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 20510.63 Da
• Isoelectric Point: 10.6895

>T112089 WP_159418169.1 NZ_CP032675:3602026-3602595 [Rhodococcus rhodochrous]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEAGFTVVLHVMLVPETMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVAEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPGALTGLG

Nucleotide

• Length: 570 bp

>T112089 NZ_CP032675:3602026-3602595 [Rhodococcus rhodochrous]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAACGGGTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGTGTGTTCGTCAACGCGGATGTGATCGCGCGGCAGCGGTGGCCCGATCGTGCCGAGGAGATGTCCTATGAGG
CGGCGCAACTCGCCGCGGCGGCGCGGGATCGGTTGCTGCGGCAGGGCCGGTCGTTCATCGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGCTGATCGACCGCGCGCACGAGGCGGGGTTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGAC
GATGTCGGTGCTGCGTGTGCAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATCCGGGCGCGCTATC
GACGGTTGTGGCCGCTGGTGGCCGAGGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCGGGTGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGGTGGGCGCCGGGGGCGCTCACCGG
GCTCGGCTGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14080.57 Da
• Isoelectric Point: 4.7096

>AT112089 WP_120282896.1 NZ_CP032675:3601643-3602029 [Rhodococcus rhodochrous]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLARTDYVEILAARGVTTVVLDDEGRLVEQRPDGSRRVLDDA

Nucleotide

• Length: 387 bp

>AT112089 NZ_CP032675:3601643-3602029 [Rhodococcus rhodochrous]
ATGACGTCGTCCACAGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
TCGCACCGGACGCCAGCAACTCGAATACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCACC
GGGTGCACGAGGCGCTGGCCGGGACGCGGGAGCTGAGCGAACTCACCGCCGCCGAGGGCCGCTTGTTCGACGCGGAGATC
GATGCGCGCCTGGCGGACGGGCTGGCCCGCACCGACTACGTCGAGATCCTCGCCGCGCGTGGGGTCACCACGGTGGTGCT
CGACGACGAGGGCCGGTTGGTCGAGCAGCGTCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA