Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2671802..2672358 Replicon chromosome
Accession NZ_CP032674
Organism Xanthobacter sp. YC-JY1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D7006_RS12465 Protein ID WP_237356810.1
Coordinates 2671993..2672358 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D7006_RS12460 Protein ID WP_169120256.1
Coordinates 2671802..2671996 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7006_RS12440 (D7006_12355) 2666973..2668463 - 1491 WP_169120262.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
D7006_RS12445 (D7006_12360) 2668724..2669785 + 1062 WP_169120260.1 glycosyltransferase family 2 protein -
D7006_RS12450 (D7006_12365) 2669865..2671349 - 1485 WP_237356809.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
D7006_RS12455 (D7006_12370) 2671346..2671633 - 288 WP_024278942.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
D7006_RS12460 (D7006_12375) 2671802..2671996 + 195 WP_169120256.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
D7006_RS12465 (D7006_12380) 2671993..2672358 + 366 WP_237356810.1 type II toxin-antitoxin system VapC family toxin Toxin
D7006_RS12470 (D7006_12385) 2672400..2672918 + 519 WP_237356811.1 Holliday junction resolvase RuvX -
D7006_RS12475 (D7006_12390) 2673096..2674031 + 936 WP_169120239.1 AEC family transporter -
D7006_RS12480 (D7006_12395) 2674100..2674525 - 426 WP_237356812.1 hypothetical protein -
D7006_RS12485 (D7006_12400) 2674771..2675718 + 948 WP_169120235.1 aspartate carbamoyltransferase catalytic subunit -
D7006_RS12490 (D7006_12405) 2675711..2677057 + 1347 WP_237356813.1 dihydroorotase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13182.35 Da        Isoelectric Point: 5.1055

>T112087 WP_237356810.1 NZ_CP032674:2671993-2672358 [Xanthobacter sp. YC-JY1]
MILVDTSIWIDHFRQCDPRLQQVLADGSVMSHPFVIGELALGNLRQREVILDAIAALPQAIIAEPAEVLGLITTESLHGR
GIGYVDAHLIASVRLTPEAVLWTRDRRLAAVAEKLGIALEA

Download         Length: 366 bp

>T112087 NZ_CP032674:2671993-2672358 [Xanthobacter sp. YC-JY1]
ATGATTCTGGTCGATACGTCCATCTGGATCGATCATTTTCGCCAATGCGATCCGAGGCTGCAGCAGGTGCTGGCGGACGG
CTCCGTGATGTCGCATCCCTTCGTGATCGGCGAACTCGCACTGGGGAACCTGCGTCAGCGGGAGGTCATCCTGGATGCCA
TCGCCGCCTTGCCGCAGGCGATCATTGCCGAACCGGCCGAAGTGCTCGGCCTCATAACGACCGAGTCGCTCCATGGCCGA
GGGATTGGATATGTCGACGCGCACTTGATTGCGTCGGTTCGATTGACGCCGGAAGCGGTTTTGTGGACGCGCGACAGGCG
GTTGGCAGCTGTTGCGGAAAAACTGGGAATTGCGCTTGAGGCGTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7126.27 Da        Isoelectric Point: 10.6723

>AT112087 WP_169120256.1 NZ_CP032674:2671802-2671996 [Xanthobacter sp. YC-JY1]
MRTTLAIDDELLARAQALTGMTEKSALVREALKALIARESALRLARLGGSEPQLEPIRRRRPDE

Download         Length: 195 bp

>AT112087 NZ_CP032674:2671802-2671996 [Xanthobacter sp. YC-JY1]
ATGCGAACCACCCTCGCCATAGACGACGAGCTTCTCGCAAGAGCACAGGCATTGACCGGCATGACAGAGAAGTCGGCTCT
CGTGCGCGAGGCACTCAAAGCGCTGATCGCCCGCGAGAGCGCATTGCGTCTCGCCCGTCTCGGCGGGAGCGAGCCCCAGC
TTGAACCGATCCGTAGACGCCGGCCCGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References