Detailed information of TA system TA112084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3989125..3989939
• Replicon: chromosome
• Accession: NZ_CP032667
• Organism: Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: D8B36_RS19755
• Protein ID: WP_001054376.1
• Coordinates: 3989125..3989382 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: D8B36_RS19760
• Protein ID: WP_001309181.1
• Coordinates: 3989394..3989939 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8B36_RS19725	3984413..3985519	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
D8B36_RS19730	3985584..3986564	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
D8B36_RS19735	3987147..3988387	-	1241	Protein_3786	helicase YjhR	-
D8B36_RS19745	3988503..3988748	+	246	Protein_3787	GNAT family N-acetyltransferase	-
D8B36_RS19755	3989125..3989382	+	258	WP_001054376.1	hypothetical protein	Toxin
D8B36_RS19760	3989394..3989939	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
D8B36_RS19765	3989995..3990741	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
D8B36_RS19770	3990910..3991128	+	219	Protein_3791	hypothetical protein	-
D8B36_RS23250	3991166..3991282	+	117	Protein_3792	VOC family protein	-
D8B36_RS19775	3991527..3992648	+	1122	WP_000010829.1	M42 family metallopeptidase	-
D8B36_RS19780	3992645..3992923	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
D8B36_RS19785	3992935..3994248	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	3978911..3998163	19252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T112084 WP_001054376.1 NZ_CP032667:3989125-3989382 [Escherichia coli str. K-12 substr. MG1655]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T112084 NZ_CP032667:3989125-3989382 [Escherichia coli str. K-12 substr. MG1655]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT112084 WP_001309181.1 NZ_CP032667:3989394-3989939 [Escherichia coli str. K-12 substr. MG1655]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT112084 NZ_CP032667:3989394-3989939 [Escherichia coli str. K-12 substr. MG1655]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8