Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1800005..1800491 Replicon chromosome
Accession NZ_CP032666
Organism Streptococcus pyogenes strain MGAS28085

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag MGAS28085_RS09060 Protein ID WP_014407961.1
Coordinates 1800005..1800274 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag MGAS28085_RS09065 Protein ID WP_014407962.1
Coordinates 1800264..1800491 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGAS28085_RS09045 1795500..1796573 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
MGAS28085_RS09050 1796690..1798963 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
MGAS28085_RS09055 1799098..1799631 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
MGAS28085_RS09060 1800005..1800274 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MGAS28085_RS09065 1800264..1800491 - 228 WP_014407962.1 hypothetical protein Antitoxin
MGAS28085_RS09070 1800644..1801015 - 372 WP_011285302.1 DUF1492 domain-containing protein -
MGAS28085_RS09075 1801005..1801352 - 348 WP_011285303.1 DUF1492 domain-containing protein -
MGAS28085_RS09080 1801633..1801878 - 246 WP_011285304.1 hypothetical protein -
MGAS28085_RS09085 1801853..1802128 - 276 WP_014407964.1 hypothetical protein -
MGAS28085_RS09090 1802118..1802456 - 339 WP_030126557.1 replication protein -
MGAS28085_RS09095 1802498..1802764 - 267 WP_011285307.1 hypothetical protein -
MGAS28085_RS09100 1802761..1803549 - 789 WP_011285308.1 hypothetical protein -
MGAS28085_RS09490 1803640..1803798 - 159 WP_011285309.1 hypothetical protein -
MGAS28085_RS09105 1803812..1804057 - 246 WP_011285310.1 hypothetical protein -
MGAS28085_RS09110 1804053..1804379 - 327 Protein_1686 hypothetical protein -
MGAS28085_RS09495 1804381..1804554 - 174 WP_011285312.1 hypothetical protein -
MGAS28085_RS09115 1804560..1804733 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T112055 WP_014407961.1 NZ_CP032666:c1800274-1800005 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T112055 NZ_CP032666:c1800274-1800005 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT112055 WP_014407962.1 NZ_CP032666:c1800491-1800264 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT112055 NZ_CP032666:c1800491-1800264 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References