Detailed information of TA system TA112047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1307522..1308558
• Replicon: chromosome
• Accession: NZ_CP032663
• Organism: Proteus vulgaris strain CCU063

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: D7029_RS05995
• Protein ID: WP_194952115.1
• Coordinates: 1307983..1308558 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: D7029_RS05990
• Protein ID: WP_194952114.1
• Coordinates: 1307522..1307983 (+)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D7029_RS05965	1303127..1304533	+	1407	WP_023581264.1	NADP-dependent phosphogluconate dehydrogenase	-
D7029_RS05970	1304669..1305037	-	369	WP_075672530.1	helix-turn-helix transcriptional regulator	-
D7029_RS05975	1305136..1305789	+	654	WP_088493341.1	oxygen-insensitive NAD(P)H nitroreductase	-
D7029_RS05980	1305898..1306515	-	618	WP_194952112.1	NAD(P)H-dependent oxidoreductase	-
D7029_RS05985	1306517..1307299	-	783	WP_194952113.1	alpha/beta hydrolase	-
D7029_RS05990	1307522..1307983	+	462	WP_194952114.1	helix-turn-helix domain-containing protein	Antitoxin
D7029_RS05995	1307983..1308558	+	576	WP_194952115.1	PIN domain-containing protein	Toxin
D7029_RS06000	1308618..1309970	-	1353	WP_194952116.1	dicarboxylate/amino acid:cation symporter	-
D7029_RS06005	1310544..1311893	-	1350	WP_194952117.1	dicarboxylate/amino acid:cation symporter	-
D7029_RS06010	1312325..1312822	-	498	WP_194952118.1	YbaK/prolyl-tRNA synthetase associated domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21959.68 Da
• Isoelectric Point: 6.9684

>T112047 WP_194952115.1 NZ_CP032663:1307983-1308558 [Proteus vulgaris]
MNHSPYPVILDACVLYPSLLRDLLIRLGIAGLYQPQWTATIHNEWQRNLLKNRPDLTSKQIEYIATLMDKAIPSAMINGY
EELIDGLVLPDLNDRHVLAAAIRCNAETIVTFNLKDFPKEKLIKFNIEALHPDEFISDLLDLNHALVLSVIYNQRKNMKK
PAMNIQQYFESLLRQSLPMTVKSLEKYTAII

Nucleotide

• Length: 576 bp

>T112047 NZ_CP032663:1307983-1308558 [Proteus vulgaris]
ATGAATCATTCTCCTTATCCTGTCATATTAGATGCATGTGTTTTATATCCATCATTATTACGAGATTTATTAATACGCTT
AGGGATAGCAGGACTCTACCAACCGCAATGGACTGCAACTATTCATAATGAATGGCAACGTAATCTTTTAAAAAATAGAC
CTGACTTAACATCAAAACAAATAGAATATATTGCTACGCTAATGGATAAAGCAATACCAAGTGCAATGATAAATGGTTAT
GAAGAGCTTATTGATGGGTTAGTTTTACCTGATTTAAATGATAGGCATGTTTTAGCGGCTGCAATTAGATGTAATGCTGA
AACAATAGTCACTTTTAATTTAAAGGATTTTCCTAAAGAAAAACTGATTAAGTTTAATATAGAGGCACTTCACCCTGATG
AATTTATATCTGACCTTTTAGATTTAAATCATGCATTAGTGTTATCTGTAATTTACAATCAAAGAAAAAACATGAAAAAG
CCAGCAATGAATATACAGCAATATTTTGAATCTCTATTACGACAAAGTTTACCTATGACAGTCAAATCATTGGAAAAGTA
TACGGCGATTATTTAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17433.14 Da
• Isoelectric Point: 5.2752

>AT112047 WP_194952114.1 NZ_CP032663:1307522-1307983 [Proteus vulgaris]
MANLMINNMNLPDPKEIEVAIKGQRELATYLSTKLEIQKISIEDDEQNIHQIELPTSALTLLMTILGELAMGNAVQVVPV
HAELTTQEAANILNVSRPHFVKLLEEGKLPFHKTGRHRRVLFSDLMRYKNQREIESEKAMQELTDLSQELGLY

Nucleotide

• Length: 462 bp

>AT112047 NZ_CP032663:1307522-1307983 [Proteus vulgaris]
ATGGCCAATTTAATGATTAATAATATGAACTTACCAGATCCAAAGGAAATTGAGGTTGCTATAAAAGGGCAGCGAGAGCT
AGCAACTTATCTATCGACTAAATTGGAAATACAAAAAATATCAATTGAGGACGATGAGCAAAATATTCATCAAATTGAAC
TGCCAACATCAGCATTGACACTACTGATGACTATTTTGGGTGAGCTTGCTATGGGAAATGCAGTTCAGGTTGTTCCCGTT
CATGCTGAATTAACAACTCAAGAAGCCGCTAATATTTTAAATGTATCACGTCCCCATTTTGTGAAATTGTTAGAGGAAGG
CAAGTTACCATTTCATAAAACAGGTCGTCACCGCCGAGTACTCTTTTCTGATTTAATGAGATACAAAAACCAAAGAGAAA
TCGAAAGTGAGAAAGCGATGCAAGAGCTTACCGATCTTAGCCAGGAATTAGGATTATATTAA