Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1459873..1460429 Replicon chromosome
Accession NZ_CP032624
Organism Gryllotalpicola protaetiae strain 2DFW10M-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D7I44_RS07135 Protein ID WP_120788856.1
Coordinates 1460061..1460429 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D7I44_RS07130 Protein ID WP_120790840.1
Coordinates 1459873..1460064 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7I44_RS07100 1454925..1455719 - 795 WP_120788853.1 methyltransferase domain-containing protein -
D7I44_RS07105 1455846..1456619 + 774 WP_162940108.1 helix-turn-helix transcriptional regulator -
D7I44_RS07110 1456629..1457732 - 1104 WP_120790838.1 MFS transporter -
D7I44_RS18100 1457876..1458529 - 654 WP_162940109.1 GntR family transcriptional regulator -
D7I44_RS07125 1458616..1459839 + 1224 WP_120788855.1 MFS transporter -
D7I44_RS07130 1459873..1460064 + 192 WP_120790840.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
D7I44_RS07135 1460061..1460429 + 369 WP_120788856.1 type II toxin-antitoxin system VapC family toxin Toxin
D7I44_RS07140 1460446..1461138 - 693 WP_120788857.1 SDR family oxidoreductase -
D7I44_RS07145 1461222..1461770 + 549 WP_120788858.1 TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator -
D7I44_RS07150 1461876..1462703 - 828 WP_120788859.1 SDR family NAD(P)-dependent oxidoreductase -
D7I44_RS07160 1462970..1463932 + 963 WP_162940110.1 DMT family transporter -
D7I44_RS07165 1463968..1464540 + 573 WP_120788861.1 flavin reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13114.06 Da        Isoelectric Point: 4.8092

>T112026 WP_120788856.1 NZ_CP032624:1460061-1460429 [Gryllotalpicola protaetiae]
VILVDTSVWVDHLHRADARLIELLDSDDVATHPMVVAELALGSLANRRGILEGLAALPFAFRAVDDELLELIDARTLWSK
GLSAVDAHLLASALITPGTQLWTRDKRLASAAAQLGVAWSPS

Download         Length: 369 bp

>T112026 NZ_CP032624:1460061-1460429 [Gryllotalpicola protaetiae]
GTGATCCTCGTCGACACGTCGGTGTGGGTCGACCACCTGCACCGCGCCGACGCCCGGTTGATCGAGCTGCTCGATTCCGA
CGATGTGGCGACGCACCCGATGGTGGTCGCCGAACTCGCCCTCGGCTCGCTCGCGAACCGGCGCGGCATTCTGGAAGGAC
TTGCCGCGCTGCCGTTCGCGTTCCGCGCCGTGGATGACGAACTGCTCGAGCTCATCGACGCGCGCACGCTCTGGTCGAAA
GGCCTCAGTGCCGTGGACGCCCACCTGCTGGCATCCGCCCTCATCACCCCGGGCACCCAACTCTGGACTCGCGACAAACG
GCTCGCGTCTGCCGCGGCTCAGCTCGGCGTCGCGTGGTCGCCGAGCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6861.84 Da        Isoelectric Point: 11.5457

>AT112026 WP_120790840.1 NZ_CP032624:1459873-1460064 [Gryllotalpicola protaetiae]
MRTTVTLDDALIARAMEMTGITERSALVRHALERLVQHEAGRRLAALGGSDPHATAAPRRRGE

Download         Length: 192 bp

>AT112026 NZ_CP032624:1459873-1460064 [Gryllotalpicola protaetiae]
ATGCGCACGACGGTCACCCTCGACGATGCACTCATCGCGCGGGCAATGGAAATGACCGGAATCACTGAGCGCTCCGCCCT
TGTACGGCACGCGTTGGAGCGTCTGGTTCAACACGAGGCCGGGCGACGGCTCGCGGCACTGGGGGGTTCCGATCCGCATG
CGACGGCCGCGCCCAGGCGCCGCGGCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References