Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2958138..2958730 Replicon chromosome
Accession NZ_CP032619
Organism Pectobacterium carotovorum strain HG-49

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag D7Z95_RS13350 Protein ID WP_181845790.1
Coordinates 2958138..2958392 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag D7Z95_RS13355 Protein ID WP_181845791.1
Coordinates 2958389..2958730 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7Z95_RS13335 2954530..2955081 + 552 WP_181829950.1 polymer-forming cytoskeletal protein -
D7Z95_RS13340 2955118..2957838 + 2721 WP_205947204.1 CRISPR-associated helicase Cas3' -
D7Z95_RS13345 2957891..2958078 + 188 Protein_2598 transcriptional regulator -
D7Z95_RS13350 2958138..2958392 + 255 WP_181845790.1 type II toxin-antitoxin system HicA family toxin Toxin
D7Z95_RS13355 2958389..2958730 + 342 WP_181845791.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
D7Z95_RS13360 2959291..2960865 + 1575 WP_205947203.1 type I-E CRISPR-associated protein Cse1/CasA -
D7Z95_RS13365 2960849..2961481 + 633 WP_205947202.1 type I-E CRISPR-associated protein Cse2/CasB -
D7Z95_RS13370 2961485..2962552 + 1068 WP_180778445.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
D7Z95_RS13375 2962562..2963296 + 735 WP_205947201.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9554.01 Da        Isoelectric Point: 11.0200

>T112014 WP_181845790.1 NZ_CP032619:2958138-2958392 [Pectobacterium carotovorum]
MNKRHQKTLSDLFSRPVNGSIKWSDIESLFVALGAEIHEREGSRIAVLLQGEKKIFHRPHPRPTTDKGAVNSIRIWLESL
GVRP

Download         Length: 255 bp

>T112014 NZ_CP032619:2958138-2958392 [Pectobacterium carotovorum]
ATGAACAAACGACACCAAAAAACGCTGTCAGATCTGTTTTCTCGTCCAGTTAATGGTTCAATAAAATGGAGTGACATAGA
ATCTCTCTTTGTTGCTCTGGGGGCTGAGATTCATGAAAGGGAAGGTTCTAGGATCGCGGTATTGTTGCAAGGTGAGAAAA
AAATTTTCCATCGGCCACATCCTAGACCGACCACTGATAAAGGGGCGGTTAACTCCATTCGGATATGGTTAGAAAGTTTA
GGAGTAAGACCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12358.99 Da        Isoelectric Point: 4.5805

>AT112014 WP_181845791.1 NZ_CP032619:2958389-2958730 [Pectobacterium carotovorum]
MINKLLIDGHPAVIAFDSEIEMFRGEFIGLNGGADFYAYSVDELKKEGATSLAIFLDECRRDGIEPYKSYSGKVTTRLTP
ERHAALAVAAQATGVSINELLNEGVDLVLERHS

Download         Length: 342 bp

>AT112014 NZ_CP032619:2958389-2958730 [Pectobacterium carotovorum]
ATGATTAATAAACTTCTTATCGATGGCCATCCTGCCGTTATTGCTTTTGACTCGGAAATTGAAATGTTCCGGGGAGAATT
TATTGGCTTGAATGGCGGCGCTGATTTTTACGCCTATAGCGTTGATGAACTGAAAAAAGAAGGGGCAACCTCTCTCGCTA
TTTTCCTTGATGAATGTCGCCGTGATGGTATTGAACCCTATAAATCCTACAGTGGAAAAGTCACAACGCGCTTGACGCCA
GAGCGTCATGCTGCGCTGGCGGTAGCGGCGCAGGCGACCGGAGTTTCCATTAACGAATTGTTAAACGAAGGCGTCGATTT
GGTTCTTGAACGACATTCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References