Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 744269..744822 Replicon chromosome
Accession NZ_CP032619
Organism Pectobacterium carotovorum strain HG-49

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag D7Z95_RS03430 Protein ID WP_205947862.1
Coordinates 744269..744583 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag D7Z95_RS03435 Protein ID WP_205947861.1
Coordinates 744586..744822 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7Z95_RS03415 739433..739867 - 435 WP_205947864.1 restriction endonuclease -
D7Z95_RS03420 739876..741099 - 1224 WP_264042456.1 hypothetical protein -
D7Z95_RS03425 741093..743576 - 2484 WP_264042458.1 RNA-directed DNA polymerase -
D7Z95_RS03430 744269..744583 - 315 WP_205947862.1 CcdB family protein Toxin
D7Z95_RS03435 744586..744822 - 237 WP_205947861.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
D7Z95_RS03440 745141..746088 - 948 WP_205947860.1 zincin-like metallopeptidase domain-containing protein -
D7Z95_RS03445 746342..746626 + 285 WP_241007308.1 JAB domain-containing protein -
D7Z95_RS03450 747104..748099 + 996 WP_205947859.1 restriction endonuclease -
D7Z95_RS03455 748096..749184 + 1089 WP_205947858.1 hypothetical protein -
D7Z95_RS03460 749181..749675 + 495 WP_205947857.1 threonine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 685382..753712 68330


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11549.50 Da        Isoelectric Point: 7.9859

>T112008 WP_205947862.1 NZ_CP032619:c744583-744269 [Pectobacterium carotovorum]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPIQALG
AVFCDASQYRTQVKAAIDFLIDGF

Download         Length: 315 bp

>T112008 NZ_CP032619:c744583-744269 [Pectobacterium carotovorum]
ATGCAATTCACTGTATACGGGAATACCGGGAAAAGCGTTGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAATTGAATCGTCGGATAGTGATCCCATTGCTCCCGATTGAAAAGTATCCGGCAGGCCGCCGACCGGATCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACCCACGAGCTGGCAAGTATCCCTATCCAGGCTCTGGGT
GCGGTGTTTTGTGATGCTTCTCAGTACCGTACTCAGGTAAAGGCTGCAATAGACTTCCTCATCGACGGGTTCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8930.00 Da        Isoelectric Point: 6.4550

>AT112008 WP_205947861.1 NZ_CP032619:c744822-744586 [Pectobacterium carotovorum]
MTAKQRNTQSVTMSVERALLVRAREAGINLSATLTTALDAELRCHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp

>AT112008 NZ_CP032619:c744822-744586 [Pectobacterium carotovorum]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGTCAGTAGAGCGTGCCTTACTGGTAAGAGCGCGTGAGGCGGG
TATTAATCTGAGTGCTACCCTGACAACCGCCCTGGATGCAGAGCTTCGCTGCCATGAAGCGAAAAAATGGCAAGAAGAAA
ACAGGGAGGCTCTCGCAGCACTAAATCGTTTTCATGATGAGCAGGGTTGTTTCAGCGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References