Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5931880..5933588 Replicon chromosome
Accession NZ_CP032618
Organism Pseudomonas fluorescens strain PF08

Toxin (Protein)


Gene name doc Uniprot ID A0A7Y0VQ10
Locus tag D7M10_RS27530 Protein ID WP_057961191.1
Coordinates 5931880..5932758 (+) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag D7M10_RS27535 Protein ID WP_057440549.1
Coordinates 5932755..5933588 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7M10_RS27505 5927873..5928724 + 852 WP_081044351.1 ABC transporter ATP-binding protein -
D7M10_RS27510 5928764..5929756 + 993 WP_057961189.1 ABC transporter substrate-binding protein -
D7M10_RS27515 5929785..5930558 + 774 WP_057440547.1 ABC transporter permease -
D7M10_RS27520 5930558..5931322 + 765 WP_120734475.1 SDR family oxidoreductase -
D7M10_RS27525 5931336..5931875 + 540 WP_029289969.1 cupin domain-containing protein -
D7M10_RS27530 5931880..5932758 + 879 WP_057961191.1 alpha/beta hydrolase Toxin
D7M10_RS27535 5932755..5933588 + 834 WP_057440549.1 IclR family transcriptional regulator Antitoxin
D7M10_RS27540 5933590..5934387 + 798 WP_057961192.1 SDR family oxidoreductase -
D7M10_RS27545 5934380..5936083 + 1704 WP_120734357.1 thiamine pyrophosphate-binding protein -
D7M10_RS27550 5936094..5936897 + 804 WP_057444232.1 aspartate dehydrogenase -
D7M10_RS27555 5936908..5938401 + 1494 WP_057440552.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilJ / pilH / pilG / pilT / algR / algC / tagR / tagT / ppkA / pppA / icmF1/tssM1 / dotU1 / hsiJ1 / fha1 / hsiB1/vipA / hsiC1/vipB / hcp1 / hsiF1 / hsiG1 / hsiH1 / clpV1 / vgrG1a 5479228..5952350 473122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(45-276)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 30998.44 Da        Isoelectric Point: 8.2675

>T112007 WP_057961191.1 NZ_CP032618:5931880-5932758 [Pseudomonas fluorescens]
MLPGLTHAAPTADLQAQLQRDFPQQRVASAGGQQALRVCGTGPAVVLLHGIGSGAASWLQVAQHLASQARVIAWDAPGYG
DSSPLESQVPKAEQYAARLVQMLDALEVDECVLVGHSLGALTALALARSAQARRVSRLVLISPARGYGAPERNAQRQQVR
QQRLDNLQRLGIAGLAEQRSAHMLSPSAQPQALAWVHWNMARLNPLGYRQAIELLCGDDLLRHGQPAMPCEVHCGEADSI
TPPDTCLGVAKALGASFNLIADAGHASPIEQPRVVAGRLAYALKQSLTGRTL

Download         Length: 879 bp

>T112007 NZ_CP032618:5931880-5932758 [Pseudomonas fluorescens]
ATGTTGCCAGGACTCACGCACGCCGCGCCGACGGCCGACCTGCAAGCCCAACTGCAGCGCGATTTCCCCCAGCAACGGGT
CGCGTCAGCAGGAGGCCAGCAGGCCCTGCGGGTATGCGGCACGGGACCGGCAGTGGTGTTGCTGCACGGCATCGGCTCGG
GCGCGGCGTCCTGGCTGCAGGTGGCACAACATCTGGCGTCCCAGGCGCGGGTCATCGCCTGGGACGCGCCCGGCTATGGC
GACTCCAGCCCCCTGGAGTCGCAAGTACCCAAGGCCGAGCAATACGCCGCGCGCCTGGTGCAGATGCTCGATGCGCTGGA
GGTGGACGAGTGCGTGCTGGTCGGCCATTCCCTGGGCGCACTGACCGCCCTGGCCTTGGCCCGCAGTGCCCAGGCCAGAC
GCGTGAGCCGCCTGGTACTGATCAGCCCCGCTCGCGGCTATGGCGCGCCCGAGCGCAACGCGCAGCGCCAGCAAGTGCGC
CAGCAACGCCTGGACAACCTGCAACGCCTGGGCATCGCCGGGCTGGCCGAGCAGCGCAGCGCCCACATGCTCTCGCCCAG
TGCCCAGCCCCAAGCGTTGGCCTGGGTGCACTGGAACATGGCCCGCCTGAACCCGCTGGGCTATCGCCAGGCCATCGAAT
TGCTGTGCGGCGACGACTTGCTGCGCCACGGCCAACCTGCAATGCCCTGCGAGGTGCATTGCGGCGAAGCCGACAGCATC
ACCCCACCCGACACCTGCCTGGGCGTGGCCAAGGCCCTGGGTGCCAGCTTCAACCTGATCGCCGACGCAGGCCATGCCAG
CCCCATCGAACAACCGCGAGTGGTTGCCGGTCGCCTGGCCTACGCCCTCAAACAATCCCTGACAGGTAGAACCCTATGA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30792.26 Da        Isoelectric Point: 6.4976

>AT112007 WP_057440549.1 NZ_CP032618:5932755-5933588 [Pseudomonas fluorescens]
MNDSDLLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRVNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSHCTPKTVMELFDMLQADRQRGFVSGEGFFESAISTVAAPVRDQSGDIVAALGVTIPTTQIGHVNF
EELLNQVRRSADELSRLLNYNGGAHSGQPRVTALMRD

Download         Length: 834 bp

>AT112007 NZ_CP032618:5932755-5933588 [Pseudomonas fluorescens]
ATGAACGACTCAGATCTGCTGAAGGATGCTCAGGACAAATACATCGTGCCGGGCCTGGAGCGCGGCTTGTTGCTGCTCTG
CGAGTTCAGCCGGCGCAACCGGACCCTGACCGCGCCGGAACTGGCGCGGCGCCTGGCGCTGCCGCGCTCGACGATTTTCC
GCTTGCTGACCACCCTGGAAACCATGGGCTTCGTCACCCGCAGCGGCAACGAGTACCGCCTGGGCATGTCGGTGCTGCGC
CTGGGCTTCGAGTACCTGGCGTCGCTGGAGCTGACCGAACTCGGCCAGCCACTGCTGGCGCGTTTGTGCGACCGGGTTAA
CTACCCGAGCAACCTGGTGGTGCGCGACGGGCGTTCCATCGTGTACGTGGCCAAGGTGTCGCCGCCTTCGGTGTTCTCCA
ACGCGGTCAACGTCGGCACCCGCCTGCCGGCCCATGCCACGGTGCTGGGGCGCATCCTCCTCGAAGACCTGTCACTGGCC
GAACTGCGCGAGCTGTACCCCGAGGAGCACCTGGAACAGCACTCCCACTGCACCCCGAAAACCGTGATGGAGCTGTTCGA
CATGCTCCAGGCCGACCGCCAGCGCGGCTTTGTCAGCGGCGAAGGGTTCTTTGAATCGGCGATTTCCACAGTGGCCGCGC
CCGTGCGCGACCAGAGCGGCGACATCGTGGCCGCCCTCGGCGTGACCATCCCGACCACGCAGATCGGTCATGTGAATTTT
GAAGAGCTGCTGAACCAAGTGCGGCGCAGCGCCGACGAGCTGTCGCGCCTGCTCAACTACAACGGCGGCGCCCACAGCGG
GCAGCCCCGCGTCACTGCCTTGATGAGAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y0VQ10

Antitoxin

Source ID Structure

References