Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1814749..1815366 Replicon chromosome
Accession NZ_CP032618
Organism Pseudomonas fluorescens strain PF08

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag D7M10_RS08465 Protein ID WP_057438840.1
Coordinates 1814749..1814937 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag D7M10_RS08470 Protein ID WP_057438841.1
Coordinates 1814962..1815366 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7M10_RS08435 1809855..1810697 + 843 WP_057438836.1 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ -
D7M10_RS08440 1810658..1811467 + 810 WP_120734408.1 phosphonate C-P lyase system protein PhnK -
D7M10_RS08445 1811464..1812186 + 723 WP_120732262.1 phosphonate C-P lyase system protein PhnL -
D7M10_RS08450 1812176..1813321 + 1146 WP_057438838.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
D7M10_RS08455 1813321..1813887 + 567 WP_057444570.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
D7M10_RS08460 1813878..1814627 + 750 WP_057958969.1 phosphonate metabolism protein PhnP -
D7M10_RS08465 1814749..1814937 + 189 WP_057438840.1 type II toxin-antitoxin system HicA family toxin Toxin
D7M10_RS08470 1814962..1815366 + 405 WP_057438841.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
D7M10_RS08475 1815725..1817239 + 1515 WP_162947790.1 M10 family metallopeptidase C-terminal domain-containing protein -
D7M10_RS08480 1817263..1818459 - 1197 WP_057438842.1 MFS transporter -
D7M10_RS08485 1818690..1819694 - 1005 WP_057438843.1 sulfate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7132.31 Da        Isoelectric Point: 11.4962

>T112004 WP_057438840.1 NZ_CP032618:1814749-1814937 [Pseudomonas fluorescens]
VQSRLLIKELQEAGWVLDRVMGSHHIFTHRYNPSTIPVPHPKKDLPLGTVRSIRQRAGLFSF

Download         Length: 189 bp

>T112004 NZ_CP032618:1814749-1814937 [Pseudomonas fluorescens]
GTGCAAAGCAGGCTATTGATCAAGGAACTGCAAGAGGCGGGCTGGGTGTTGGATCGGGTCATGGGCAGCCATCACATTTT
CACCCATCGCTATAACCCGTCCACGATACCGGTGCCCCATCCCAAGAAGGATCTGCCCTTGGGCACCGTGCGAAGTATCC
GGCAGCGTGCCGGGTTGTTTTCGTTCTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14706.68 Da        Isoelectric Point: 4.6115

>AT112004 WP_057438841.1 NZ_CP032618:1814962-1815366 [Pseudomonas fluorescens]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHILLQELAGEGRAIPMPTSVATHHGNEEYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT112004 NZ_CP032618:1814962-1815366 [Pseudomonas fluorescens]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTACCGCCACCGGTATCCAGATCCCTGATATTCCAGGCGCGGT
GACGGCCGGGGACAGTTTTGAAGAGGCTTACAACGCCGCCGTCGAAGTGGCTCACATCCTGTTGCAGGAGCTGGCTGGCG
AAGGCCGCGCGATTCCGATGCCGACCTCGGTGGCGACGCACCACGGCAATGAGGAGTACGCCGGGATGGGCTGGGGGATG
CTCGAGCTCGATATCTCGCCTTACCTGGGCAAGACCGAGAAGGTCAATGTCACGTTGCCGGGGTATGTGATCCAGCGTAT
TGACCGTTATGTGCGCGAGCACAAGGTCAAAAGTCGCTCGTCATTCCTGGCGGATGCGGCGCTGGAGAAGTTGGTGCGTT
CTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References