Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 5192483..5193461 Replicon chromosome
Accession NZ_CP032608
Organism Bacillus thuringiensis strain QZL38

Toxin (Protein)


Gene name spoIISA Uniprot ID M1Q940
Locus tag D7J84_RS26590 Protein ID WP_000624982.1
Coordinates 5192724..5193461 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag D7J84_RS26585 Protein ID WP_046946297.1
Coordinates 5192483..5192611 (-) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7J84_RS26555 5187968..5188219 + 252 WP_000827560.1 response regulator transcription factor -
D7J84_RS26560 5188461..5189063 - 603 WP_000517278.1 hypothetical protein -
D7J84_RS26565 5189089..5189898 - 810 WP_000678378.1 C39 family peptidase -
D7J84_RS26570 5190144..5191613 - 1470 WP_061884163.1 beta-Ala-His dipeptidase -
D7J84_RS26575 5191825..5192214 + 390 WP_000714181.1 YxeA family protein -
D7J84_RS26580 5192234..5192410 - 177 WP_000852629.1 stage II sporulation protein SB -
D7J84_RS26585 5192483..5192611 - 129 WP_046946297.1 hypothetical protein Antitoxin
D7J84_RS26590 5192724..5193461 - 738 WP_000624982.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
D7J84_RS26595 5193700..5194437 - 738 WP_000594147.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
D7J84_RS26600 5194604..5195086 - 483 WP_000191914.1 MarR family winged helix-turn-helix transcriptional regulator -
D7J84_RS26610 5195326..5196183 + 858 Protein_5098 alpha-keto acid decarboxylase family protein -
D7J84_RS26615 5196341..5196721 - 381 WP_000497668.1 methyltransferase -
D7J84_RS26620 5196743..5197150 - 408 WP_000063589.1 VOC family protein -
D7J84_RS26625 5197266..5197976 - 711 WP_000787493.1 class I SAM-dependent methyltransferase -
D7J84_RS26630 5198099..5198375 - 277 Protein_5102 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28323.03 Da        Isoelectric Point: 8.2998

>T111991 WP_000624982.1 NZ_CP032608:c5193461-5192724 [Bacillus thuringiensis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPSVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T111991 NZ_CP032608:c5193461-5192724 [Bacillus thuringiensis]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTTTGGAAGAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCATTC
ATTTTAACACCTAATATTTCAGAAATATGGGGTGCCAAATTTAGCGATATTGGCAAGACAGTTCAATCAATCAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCATCAGTTTTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATACGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTACAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4952.37 Da        Isoelectric Point: 4.0548

>AT111991 WP_046946297.1 NZ_CP032608:c5192611-5192483 [Bacillus thuringiensis]
VVKNYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT111991 NZ_CP032608:c5192611-5192483 [Bacillus thuringiensis]
GTGGTAAAAAATTATGACAATGATTTTTTTAAAGAAGGTAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M1Q940

Antitoxin

Source ID Structure

References