Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6824294..6824799 Replicon chromosome
Accession NZ_CP032569
Organism Pseudomonas aeruginosa strain BA7823

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag D7H65_RS32565 Protein ID WP_031640969.1
Coordinates 6824294..6824575 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag D7H65_RS32570 Protein ID WP_003083775.1
Coordinates 6824572..6824799 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7H65_RS32540 6819545..6820894 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
D7H65_RS32545 6820943..6821629 + 687 WP_003083762.1 FadR family transcriptional regulator -
D7H65_RS32550 6821730..6822464 + 735 WP_003128333.1 GntR family transcriptional regulator -
D7H65_RS32555 6822668..6823054 + 387 WP_003083767.1 aegerolysin family protein -
D7H65_RS32560 6823086..6823994 - 909 WP_033990895.1 LysR family transcriptional regulator -
D7H65_RS32565 6824294..6824575 - 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
D7H65_RS32570 6824572..6824799 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
D7H65_RS32575 6824975..6825595 - 621 WP_003101226.1 hypothetical protein -
D7H65_RS32580 6825696..6826196 + 501 WP_003101228.1 LEA type 2 family protein -
D7H65_RS32585 6826268..6826609 + 342 WP_003101229.1 alkylphosphonate utilization protein -
D7H65_RS32590 6826691..6828118 - 1428 WP_003083784.1 GABA permease -
D7H65_RS32595 6828286..6829779 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T111989 WP_031640969.1 NZ_CP032569:c6824575-6824294 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T111989 NZ_CP032569:c6824575-6824294 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGAACCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT111989 WP_003083775.1 NZ_CP032569:c6824799-6824572 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT111989 NZ_CP032569:c6824799-6824572 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References