Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 6824294..6824799 | Replicon | chromosome |
Accession | NZ_CP032569 | ||
Organism | Pseudomonas aeruginosa strain BA7823 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A3S3VVC5 |
Locus tag | D7H65_RS32565 | Protein ID | WP_031640969.1 |
Coordinates | 6824294..6824575 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A1C7BDS9 |
Locus tag | D7H65_RS32570 | Protein ID | WP_003083775.1 |
Coordinates | 6824572..6824799 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D7H65_RS32540 | 6819545..6820894 | + | 1350 | WP_003137006.1 | C4-dicarboxylate transporter DctA | - |
D7H65_RS32545 | 6820943..6821629 | + | 687 | WP_003083762.1 | FadR family transcriptional regulator | - |
D7H65_RS32550 | 6821730..6822464 | + | 735 | WP_003128333.1 | GntR family transcriptional regulator | - |
D7H65_RS32555 | 6822668..6823054 | + | 387 | WP_003083767.1 | aegerolysin family protein | - |
D7H65_RS32560 | 6823086..6823994 | - | 909 | WP_033990895.1 | LysR family transcriptional regulator | - |
D7H65_RS32565 | 6824294..6824575 | - | 282 | WP_031640969.1 | type II toxin-antitoxin system toxin ParE | Toxin |
D7H65_RS32570 | 6824572..6824799 | - | 228 | WP_003083775.1 | CopG family ribbon-helix-helix protein | Antitoxin |
D7H65_RS32575 | 6824975..6825595 | - | 621 | WP_003101226.1 | hypothetical protein | - |
D7H65_RS32580 | 6825696..6826196 | + | 501 | WP_003101228.1 | LEA type 2 family protein | - |
D7H65_RS32585 | 6826268..6826609 | + | 342 | WP_003101229.1 | alkylphosphonate utilization protein | - |
D7H65_RS32590 | 6826691..6828118 | - | 1428 | WP_003083784.1 | GABA permease | - |
D7H65_RS32595 | 6828286..6829779 | - | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10475.19 Da Isoelectric Point: 10.0435
>T111989 WP_031640969.1 NZ_CP032569:c6824575-6824294 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T111989 NZ_CP032569:c6824575-6824294 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGAACCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGAACCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8556.58 Da Isoelectric Point: 5.5740
>AT111989 WP_003083775.1 NZ_CP032569:c6824799-6824572 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
Download Length: 228 bp
>AT111989 NZ_CP032569:c6824799-6824572 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S3VVC5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1C7BDS9 |