Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2281776..2282292 Replicon chromosome
Accession NZ_CP032569
Organism Pseudomonas aeruginosa strain BA7823

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag D7H65_RS11205 Protein ID WP_025297453.1
Coordinates 2282011..2282292 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag D7H65_RS11200 Protein ID WP_025297454.1
Coordinates 2281776..2282021 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7H65_RS11185 2277070..2277948 + 879 WP_140786425.1 sel1 repeat family protein -
D7H65_RS32900 2278023..2279390 + 1368 WP_181182513.1 hypothetical protein -
D7H65_RS11195 2279477..2281618 + 2142 WP_140786426.1 NERD domain-containing protein -
D7H65_RS11200 2281776..2282021 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
D7H65_RS11205 2282011..2282292 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D7H65_RS11210 2282698..2283279 - 582 WP_162500782.1 plasmid pRiA4b ORF-3 family protein -
D7H65_RS11215 2283293..2284168 - 876 WP_140786427.1 WYL domain-containing protein -
D7H65_RS11220 2284298..2285878 + 1581 WP_140786428.1 DNA recombination protein RmuC -
D7H65_RS11225 2285902..2286549 + 648 WP_043106453.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2260456..2326081 65625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T111982 WP_025297453.1 NZ_CP032569:2282011-2282292 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

>T111982 NZ_CP032569:2282011-2282292 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGTCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGTGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT111982 WP_025297454.1 NZ_CP032569:2281776-2282021 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp

>AT111982 NZ_CP032569:2281776-2282021 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References