Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3350742..3351518 Replicon chromosome
Accession NZ_CP032566
Organism Yersinia pseudotuberculosis strain IP2666pIB1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H3B6R1
Locus tag DN756_RS15580 Protein ID WP_012304462.1
Coordinates 3350742..3351125 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H3B780
Locus tag DN756_RS15585 Protein ID WP_012304463.1
Coordinates 3351189..3351518 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DN756_RS15550 3346788..3347243 - 456 WP_012304457.1 antitermination protein -
DN756_RS15560 3347369..3347698 + 330 WP_050756398.1 hypothetical protein -
DN756_RS15565 3347869..3349023 + 1155 WP_012304459.1 site-specific integrase -
DN756_RS15570 3349227..3350075 - 849 WP_012304460.1 DUF4942 domain-containing protein -
DN756_RS15575 3350250..3350745 - 496 Protein_2917 hypothetical protein -
DN756_RS15580 3350742..3351125 - 384 WP_012304462.1 TA system toxin CbtA family protein Toxin
DN756_RS15585 3351189..3351518 - 330 WP_012304463.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DN756_RS15590 3351531..3352001 - 471 WP_012304464.1 DNA repair protein RadC -
DN756_RS15595 3352072..3352893 - 822 WP_012304465.1 DUF945 domain-containing protein -
DN756_RS15600 3352982..3353320 - 339 WP_012304466.1 hypothetical protein -
DN756_RS15605 3353341..3353805 - 465 WP_012304467.1 hypothetical protein -
DN756_RS15620 3354306..3355193 - 888 WP_012304468.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14442.40 Da        Isoelectric Point: 8.9291

>T111978 WP_012304462.1 NZ_CP032566:c3351125-3350742 [Yersinia pseudotuberculosis]
MQTLPVNPKRAAQTCPSPVEIWQKLLTHLLDQHYGLTLSDTSFSNETTIREHIDAGISLSYAVNFLVEKYELVRTDRTSF
TIVEQSPFITPIDILRARQATGLLKRSGYKAVSDITRGRARREEQSH

Download         Length: 384 bp

>T111978 NZ_CP032566:c3351125-3350742 [Yersinia pseudotuberculosis]
ATGCAAACCTTACCCGTAAACCCGAAACGGGCGGCACAAACCTGCCCGTCACCTGTTGAAATATGGCAAAAACTGCTAAC
GCATCTGCTCGATCAACACTATGGACTCACACTTAGTGATACCTCGTTCAGCAATGAAACCACCATCCGTGAACATATTG
ACGCCGGAATATCCCTCAGCTATGCGGTGAACTTCCTGGTGGAAAAATATGAACTGGTACGCACTGACCGGACCAGTTTC
ACCATTGTGGAGCAATCACCGTTTATCACCCCAATCGATATTCTCCGCGCCAGGCAAGCCACCGGTCTCCTGAAGCGCAG
TGGTTATAAAGCCGTCAGTGACATTACCCGTGGCAGAGCTCGGCGAGAGGAGCAAAGCCATTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12234.84 Da        Isoelectric Point: 6.4825

>AT111978 WP_012304463.1 NZ_CP032566:c3351518-3351189 [Yersinia pseudotuberculosis]
MSLTLSHEWGLKSDITPRFGARLVQEGNRLHFRADHAGFNGAFSEDEALRLDQAFPLMLKQLELKLLSGELNPRRQHCVT
LNHNGLTCEADTLGSHGYVYITIYPASPE

Download         Length: 330 bp

>AT111978 NZ_CP032566:c3351518-3351189 [Yersinia pseudotuberculosis]
ATGTCATTAACACTATCCCATGAATGGGGGCTAAAAAGCGATATCACCCCACGCTTTGGCGCAAGATTGGTGCAGGAAGG
CAATCGCCTGCACTTTCGGGCTGACCATGCGGGTTTTAACGGTGCATTCAGTGAGGATGAGGCGCTGCGGCTTGACCAAG
CGTTTCCACTGATGCTCAAACAGCTTGAACTTAAGCTGCTATCCGGTGAGCTCAATCCTCGTCGTCAGCATTGCGTTACG
TTGAACCACAATGGCCTGACCTGCGAAGCTGACACCCTCGGCTCTCACGGGTATGTCTATATCACTATTTACCCGGCAAG
CCCGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3B6R1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3B780

References