111961

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 151305..151810 Replicon chromosome
Accession NZ_CP032552
Organism Pseudomonas aeruginosa strain PA34

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PA34_RS00705 Protein ID WP_003083773.1
Coordinates 151305..151586 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PA34_RS00710 Protein ID WP_003083775.1
Coordinates 151583..151810 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA34_RS00680 146556..147905 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PA34_RS00685 147954..148640 + 687 WP_003083762.1 FadR family transcriptional regulator -
PA34_RS00690 148741..149475 + 735 WP_003110658.1 GntR family transcriptional regulator -
PA34_RS00695 149679..150065 + 387 WP_003083767.1 aegerolysin family protein -
PA34_RS00700 150097..151005 - 909 WP_003083769.1 LysR family transcriptional regulator -
PA34_RS00705 151305..151586 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PA34_RS00710 151583..151810 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PA34_RS00715 151986..152606 - 621 WP_003101226.1 hypothetical protein -
PA34_RS00720 152707..153207 + 501 WP_033990064.1 LEA type 2 family protein -
PA34_RS00725 153280..153621 + 342 WP_024947024.1 alkylphosphonate utilization protein -
PA34_RS00730 153703..155130 - 1428 WP_023092260.1 GABA permease -
PA34_RS00735 155298..156791 - 1494 WP_024947023.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T111961 WP_003083773.1 NZ_CP032552:c151586-151305 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T111961 NZ_CP032552:c151586-151305 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT111961 WP_003083775.1 NZ_CP032552:c151810-151583 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT111961 NZ_CP032552:c151810-151583 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCGGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References