Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 1812029..1813491 Replicon chromosome
Accession NZ_CP032538
Organism Bacillus licheniformis strain MT-B06

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag D6022_RS09475 Protein ID WP_017474550.1
Coordinates 1812029..1812739 (+) Length 237 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag D6022_RS09480 Protein ID WP_017474549.1
Coordinates 1812742..1813491 (+) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D6022_RS09430 1807125..1807307 + 183 WP_017474916.1 XkdX family protein -
D6022_RS09435 1807408..1808241 + 834 WP_017474917.1 hypothetical protein -
D6022_RS09440 1808324..1808593 + 270 WP_017474918.1 hemolysin XhlA family protein -
D6022_RS09445 1808609..1808872 + 264 WP_017474919.1 phage holin -
D6022_RS09450 1808924..1810003 + 1080 WP_075218312.1 N-acetylmuramoyl-L-alanine amidase -
D6022_RS23885 1810011..1810157 + 147 WP_017474554.1 hypothetical protein -
D6022_RS09455 1810423..1810596 - 174 WP_017474553.1 hypothetical protein -
D6022_RS09460 1810644..1811453 - 810 WP_017474552.1 ATP-dependent DNA ligase -
D6022_RS09465 1811579..1811668 + 90 Protein_1824 peptidoglycan-binding protein -
D6022_RS09470 1811674..1811757 + 84 Protein_1825 LysM peptidoglycan-binding domain-containing protein -
D6022_RS09475 1812029..1812739 + 711 WP_017474550.1 hypothetical protein Toxin
D6022_RS09480 1812742..1813491 + 750 WP_017474549.1 DUF4065 domain-containing protein Antitoxin
D6022_RS09490 1813850..1815031 - 1182 WP_016886467.1 oxalate decarboxylase family bicupin -
D6022_RS09495 1815346..1816527 + 1182 WP_003184708.1 alanine racemase -
D6022_RS09500 1816702..1817619 + 918 WP_003184707.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1760914..1813491 52577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(113-224)


Sequences

Toxin        


Download         Length: 237 a.a.        Molecular weight: 28189.80 Da        Isoelectric Point: 6.8925

>T111957 WP_017474550.1 NZ_CP032538:1812029-1812739 [Bacillus licheniformis]
VINCTCEVESFCYSFYNLIVEINEAHSEFSKEFASEKQDALINLKRKQVNHVTQVKNGNTFSVDNLFLQLISNYREKLLD
YIATDVDFESQYTDLILRARTKESTSIINKLKYYLVGKNEAGKLPLNKCLNDLFGFRIHPTFFDHNKECFQETCQRLKQL
YKNRIDFRDSSKGNYKAYHIYLYGESWEYFPWEIQVWRLSDREQNDLSHKQHKQEHRKWAAIYKNSTEIELEMEGV

Download         Length: 711 bp

>T111957 NZ_CP032538:1812029-1812739 [Bacillus licheniformis]
GTGATTAATTGTACGTGTGAAGTAGAGTCATTTTGTTATAGTTTTTATAACTTAATAGTTGAAATTAATGAAGCGCATAG
TGAATTTTCAAAAGAGTTCGCTTCTGAAAAACAAGATGCTCTAATTAACTTAAAAAGAAAACAAGTTAATCATGTTACTC
AAGTAAAAAATGGGAACACTTTTTCTGTTGATAATTTGTTTTTGCAGTTGATTTCAAATTATCGAGAGAAGTTGCTTGAT
TATATTGCAACTGATGTTGATTTTGAAAGTCAATATACGGATTTAATTCTAAGGGCAAGAACTAAGGAATCCACTTCAAT
CATTAATAAGCTTAAATATTATCTTGTTGGAAAAAATGAAGCAGGAAAACTACCTCTTAACAAATGCTTGAATGATTTAT
TTGGATTTAGAATACATCCAACATTTTTTGACCATAATAAGGAATGTTTTCAAGAGACATGTCAAAGGTTAAAGCAACTA
TATAAAAATCGAATTGATTTTAGGGATTCATCAAAGGGAAATTATAAAGCGTATCATATTTATTTATACGGAGAGAGTTG
GGAATACTTCCCTTGGGAAATACAAGTATGGCGCTTAAGTGATCGTGAACAGAATGATTTATCGCATAAGCAGCATAAAC
AAGAACATAGGAAATGGGCTGCAATTTACAAAAATTCAACAGAAATAGAATTAGAAATGGAAGGTGTTTAG

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 29056.07 Da        Isoelectric Point: 6.4106

>AT111957 WP_017474549.1 NZ_CP032538:1812742-1813491 [Bacillus licheniformis]
MAFHFIAIVSDFSGGRRYGWHYSSEDRLDKDYIKSFMTKVKQKCGHIQFGIHKLTTEDTSWASVVRMDSFFDDVIITNRI
DDFIDVVANDQQLSAYDVAKFVLATLPTSHLKLQKLLYYIYSEFLVRTGEKLFKDRIVAYKYGPVVEDVFHKYRKHGSSE
IDYKEDATFVLRTDEQAFTPSLMKIWTSEYGVAALECIIETLEKYGDLDAFRLVDKTHQKGGPWERVYKPGQNCEITDEL
ITLYHKYVQ

Download         Length: 750 bp

>AT111957 NZ_CP032538:1812742-1813491 [Bacillus licheniformis]
ATGGCTTTTCATTTTATTGCAATCGTAAGTGACTTCTCTGGTGGGAGAAGATACGGTTGGCATTATTCAAGTGAAGACAG
GTTAGATAAAGATTATATTAAGTCTTTTATGACCAAAGTTAAACAAAAATGTGGACATATTCAATTTGGAATTCATAAAC
TAACTACTGAGGATACATCTTGGGCTTCAGTAGTAAGAATGGATTCGTTCTTTGATGATGTTATAATAACAAATCGAATT
GACGACTTTATAGATGTTGTTGCAAATGATCAACAGCTTTCCGCTTATGATGTTGCTAAATTCGTACTAGCTACGCTCCC
TACATCACATTTGAAATTGCAAAAGTTGCTATACTATATCTACTCTGAATTTCTGGTCAGAACTGGGGAAAAATTATTCA
AAGATCGGATAGTTGCTTATAAGTATGGACCTGTAGTAGAAGATGTTTTTCATAAGTATCGAAAACATGGTAGCTCGGAA
ATTGATTATAAAGAGGATGCGACTTTCGTGTTGCGAACAGATGAACAAGCATTTACACCCTCTTTAATGAAAATTTGGAC
TTCTGAATATGGAGTAGCAGCGTTAGAATGTATTATAGAAACATTGGAGAAATATGGTGATCTAGATGCATTCAGGTTAG
TTGACAAAACTCATCAAAAAGGGGGGCCATGGGAAAGAGTTTATAAACCTGGTCAAAATTGTGAAATCACTGATGAGTTA
ATAACTCTATATCATAAATATGTACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References