Detailed information of TA system TA111949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 4079845..4080329
• Replicon: chromosome
• Accession: NZ_CP032523
• Organism: Shigella sonnei strain AR_0030

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A377EAU1
• Locus tag: AM357_RS21020
• Protein ID: WP_014334020.1
• Coordinates: 4080039..4080329 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A376K4R9
• Locus tag: AM357_RS21015
• Protein ID: WP_005142544.1
• Coordinates: 4079845..4080039 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM357_RS20975 (4075040)	4075040..4075396	-	357	WP_005140877.1	hypothetical protein	-
AM357_RS20980 (4075454)	4075454..4075876	-	423	WP_001151171.1	DUF977 family protein	-
AM357_RS20985 (4075892)	4075892..4076617	-	726	WP_000450631.1	DUF1627 domain-containing protein	-
AM357_RS20990 (4076639)	4076639..4077385	-	747	WP_000788740.1	ATP-binding protein	-
AM357_RS20995 (4077392)	4077392..4078456	-	1065	WP_001262380.1	hypothetical protein	-
AM357_RS21000 (4078528)	4078528..4078953	-	426	WP_000693826.1	toxin YdaT family protein	-
AM357_RS21005 (4078950)	4078950..4079213	-	264	WP_001048456.1	helix-turn-helix transcriptional regulator	-
AM357_RS21010 (4079340)	4079340..4079825	+	486	WP_053002468.1	helix-turn-helix domain-containing protein	-
AM357_RS21015 (4079845)	4079845..4080039	+	195	WP_005142544.1	hypothetical protein	Antitoxin
AM357_RS21020 (4080039)	4080039..4080329	+	291	WP_014334020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM357_RS21025 (4080608)	4080608..4080760	+	153	WP_000379558.1	DUF1391 family protein	-
AM357_RS21030 (4080772)	4080772..4081137	+	366	WP_024174355.1	hypothetical protein	-
AM357_RS27505 (4082039)	4082039..4082134	+	96	Protein_4057	transcriptional regulator	-
AM357_RS21045 (4082145)	4082145..4082333	+	189	WP_000449206.1	cell division inhibition protein DicB	-
AM357_RS21050 (4082330)	4082330..4082521	+	192	WP_001090204.1	DUF1482 family protein	-
AM357_RS21055 (4082615)	4082615..4083673	+	1059	Protein_4060	exonuclease	-
AM357_RS21065 (4084939)	4084939..4085181	+	243	Protein_4062	benzoate/H(+) symporter BenE family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4072993..4122895	49902

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.93 Da
• Isoelectric Point: 10.2013

>T111949 WP_014334020.1 NZ_CP032523:4080039-4080329 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Nucleotide

• Length: 291 bp

>T111949 NZ_CP032523:4080039-4080329 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7097.98 Da
• Isoelectric Point: 4.1759

>AT111949 WP_005142544.1 NZ_CP032523:4079845-4080039 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Nucleotide

• Length: 195 bp

>AT111949 NZ_CP032523:4079845-4080039 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A377EAU1

Antitoxin

• AlphaFold DB: A0A376K4R9