Detailed information of TA system TA111929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 422413..423071
• Replicon: plasmid unnamed1
• Accession: NZ_CP032520
• Organism: Cupriavidus oxalaticus strain T2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D2917_RS32575
• Protein ID: WP_151073202.1
• Coordinates: 422413..422823 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D2917_RS32580
• Protein ID: WP_151073203.1
• Coordinates: 422820..423071 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D2917_RS32545	417452..419758	+	2307	WP_151073201.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
D2917_RS32550	419755..420663	-	909	WP_151073278.1	LysR family transcriptional regulator	-
D2917_RS32555	420823..421692	+	870	WP_151073279.1	TniB family NTP-binding protein	-
D2917_RS32565	421773..421970	-	198	Protein_404	TniB family NTP-binding protein	-
D2917_RS32570	422127..422381	-	255	Protein_405	site-specific integrase	-
D2917_RS32575	422413..422823	-	411	WP_151073202.1	type II toxin-antitoxin system VapC family toxin	Toxin
D2917_RS32580	422820..423071	-	252	WP_151073203.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D2917_RS32585	423219..424499	-	1281	WP_167525755.1	tyrosine-type recombinase/integrase	-
D2917_RS32590	424592..425794	+	1203	WP_151073205.1	DNA-binding protein	-
D2917_RS32595	425778..425981	+	204	WP_151073206.1	H-NS histone family protein	-
D2917_RS32600	426133..426486	+	354	WP_151073207.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..568815	568815

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (8-55)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14527.94 Da
• Isoelectric Point: 6.7173

>T111929 WP_151073202.1 NZ_CP032520:c422823-422413 [Cupriavidus oxalaticus]
MTRYMLDTNIVSHLLRGHPAVVARVTAAPMATLCLSVITGAELMYGLAKRPGAARLARAVDELLRRIEVLPWPPSVMAGY
GETRAALESQGQPMGALDLLIAAHALETGAVLVTNDQAFRRVPGLVVEDWSVPTGD

Nucleotide

• Length: 411 bp

>T111929 NZ_CP032520:c422823-422413 [Cupriavidus oxalaticus]
ATGACGCGCTACATGCTTGACACTAATATCGTGAGCCATCTGCTGCGAGGACACCCAGCAGTCGTGGCACGCGTGACAGC
CGCGCCGATGGCGACGCTGTGCCTGTCGGTCATCACCGGCGCGGAACTGATGTACGGGCTGGCCAAGCGCCCCGGCGCAG
CGCGACTCGCGCGCGCAGTGGACGAGTTGCTGCGTCGGATCGAGGTGTTGCCTTGGCCCCCTTCGGTGATGGCCGGCTAT
GGTGAAACCCGCGCTGCACTGGAATCTCAAGGGCAGCCGATGGGGGCGCTGGACTTACTGATTGCCGCGCACGCGCTGGA
GACTGGCGCGGTGCTGGTGACCAATGACCAAGCGTTCCGGCGCGTCCCTGGCCTAGTGGTGGAGGACTGGTCGGTGCCAA
CCGGGGACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9280.36 Da
• Isoelectric Point: 4.7571

>AT111929 WP_151073203.1 NZ_CP032520:c423071-422820 [Cupriavidus oxalaticus]
MSTTAKIFTTGRSQAVRLPQEFRFAEREVYIRRDPSTGDVILSRRPDSWDGFLAAIQGSAVPADFLAERAQDEQPRDPLA
GLE

Nucleotide

• Length: 252 bp

>AT111929 NZ_CP032520:c423071-422820 [Cupriavidus oxalaticus]
ATGAGTACCACTGCCAAGATCTTTACCACCGGCCGCAGCCAGGCGGTGCGGCTGCCTCAGGAGTTCCGCTTTGCTGAGCG
CGAGGTCTATATCCGCCGTGACCCATCCACCGGCGACGTGATCCTGTCGCGCCGGCCGGATAGTTGGGACGGCTTCCTGG
CCGCCATCCAGGGCAGCGCCGTGCCGGCAGACTTCCTGGCCGAGCGCGCGCAGGACGAGCAACCCCGGGATCCGCTGGCG
GGTCTCGAATGA