Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1809851..1811562 Replicon chromosome
Accession NZ_CP032519
Organism Cupriavidus oxalaticus strain T2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag D2917_RS21065 Protein ID WP_151071848.1
Coordinates 1810234..1811562 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag D2917_RS21060 Protein ID WP_151071847.1
Coordinates 1809851..1810231 (+) Length 127 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D2917_RS21045 1807584..1807895 + 312 WP_151072848.1 response regulator transcription factor -
D2917_RS21050 1807924..1808571 - 648 WP_151071845.1 response regulator transcription factor -
D2917_RS21055 1808618..1809478 - 861 WP_151071846.1 universal stress protein -
D2917_RS21060 1809851..1810231 + 381 WP_151071847.1 helix-turn-helix domain-containing protein Antitoxin
D2917_RS21065 1810234..1811562 + 1329 WP_151071848.1 type II toxin-antitoxin system HipA family toxin Toxin
D2917_RS21070 1811687..1815217 + 3531 WP_151071849.1 adenylate/guanylate cyclase domain-containing protein -
D2917_RS21075 1815214..1815885 + 672 WP_063238758.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-110)

Antitoxin

(18-66)


Sequences


Toxin        


Download         Length: 443 a.a.        Molecular weight: 48689.47 Da        Isoelectric Point: 8.1855

>T111926 WP_151071848.1 NZ_CP032519:1810234-1811562 [Cupriavidus oxalaticus]
MTRGTHAKRLDLWMNGLPVGHWETTPAGDRLAYREDWIADPQGRPLSLSLPFTPGNQPHRGPVVANYFDNLLPDSDAIRR
RIAARYQTGGTDAFALLARLGRDCAGALQMLPPQEAPTALKRVQGRPLSETEIATLLHEATDEPVLGLREPIDDLRLSIA
GAQEKTALLRWDGQWLLPQGSTPTTHIFKLPMGLVGNMRADMRTSVENEWLCARIVAAFGLPVAACEIARFGDTKALVVE
RFDRKPSADGSWLLRLPQEDMCQATGTPALQKYESDGGPGIQQIADILSGSRSAPSDRRNFFRAQIVFWLLAATDGHGKN
FSISHLPGSRYEATPLYDILSAHPIIGKGRNHVAPQRARLAMALHGKNSHYAIQEIQRRHWFAQGQRIGFPPGDVGSMLD
EVMSQTSRAIDAAASALPPEFPMDLADAIFDGMRRQQRRLAA

Download         Length: 1329 bp

>T111926 NZ_CP032519:1810234-1811562 [Cupriavidus oxalaticus]
ATGACGCGCGGCACGCACGCGAAGCGTCTCGACCTGTGGATGAACGGCTTGCCGGTGGGCCACTGGGAAACCACGCCCGC
CGGCGACCGGCTGGCCTATCGCGAAGACTGGATTGCCGACCCGCAAGGCCGGCCGCTGTCCTTGTCATTGCCCTTTACGC
CGGGCAACCAGCCACACCGCGGACCGGTAGTCGCCAACTATTTCGACAACCTGCTGCCCGACAGCGATGCCATCCGGCGG
CGCATCGCGGCCCGGTACCAGACCGGCGGGACCGACGCCTTCGCGCTGCTGGCCAGGCTCGGCCGCGACTGCGCCGGCGC
CCTGCAGATGCTGCCGCCGCAGGAAGCGCCGACGGCGTTGAAGCGCGTCCAGGGCCGCCCGCTGTCGGAAACGGAGATCG
CAACCCTGCTGCACGAGGCCACGGACGAGCCCGTGCTCGGGCTGCGCGAACCCATCGATGACCTGCGCCTGTCCATCGCC
GGTGCGCAGGAAAAGACCGCGCTGCTGCGCTGGGACGGGCAATGGCTGTTGCCGCAAGGCAGTACGCCTACCACGCATAT
CTTCAAGCTGCCGATGGGACTGGTGGGCAATATGCGCGCCGACATGCGGACCTCGGTGGAAAACGAATGGCTCTGCGCCA
GGATCGTCGCCGCGTTTGGCCTGCCGGTCGCTGCCTGCGAGATCGCCCGCTTCGGGGATACCAAGGCGCTGGTCGTCGAA
CGCTTCGACCGCAAGCCCTCGGCGGACGGTTCCTGGCTGCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCCACCGGGAC
GCCGGCATTGCAGAAGTACGAGTCGGACGGCGGGCCGGGCATCCAGCAGATCGCAGACATCCTCTCCGGCTCGCGCTCGG
CGCCGTCCGATCGCCGCAACTTCTTCCGCGCGCAGATCGTCTTCTGGCTGCTCGCGGCCACGGATGGCCATGGCAAGAAC
TTCAGCATCAGCCACCTGCCGGGCAGCCGCTATGAAGCGACGCCGCTGTACGACATCCTGTCGGCGCATCCGATCATCGG
CAAAGGCAGGAACCACGTGGCGCCGCAACGGGCCCGGCTGGCGATGGCGCTGCACGGCAAGAATTCGCACTACGCCATCC
AGGAGATCCAGCGGCGGCACTGGTTTGCCCAGGGACAGCGCATCGGCTTCCCGCCCGGCGATGTCGGGTCGATGCTCGAC
GAGGTCATGTCGCAGACCAGCCGGGCCATCGACGCCGCCGCTTCCGCGCTGCCGCCGGAATTCCCCATGGATCTTGCCGA
TGCGATCTTCGATGGCATGCGCCGGCAGCAGCGGCGTCTGGCCGCCTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14128.20 Da        Isoelectric Point: 10.4444

>AT111926 WP_151071847.1 NZ_CP032519:1809851-1810231 [Cupriavidus oxalaticus]
MHYSIQTLSQLRPILQGFRKSRGLTQANMAAYLGVRQQTYAELEANPAAASVERLFKALRVLGVEMVLSPAPDTDMQPEP
EPPSGYVTPPEKDPRRATQVEQPRMPAKRKASRTALKTGQPKREDW

Download         Length: 381 bp

>AT111926 NZ_CP032519:1809851-1810231 [Cupriavidus oxalaticus]
ATGCACTATTCCATCCAGACACTCAGCCAGCTGCGGCCGATCCTGCAGGGCTTCCGGAAATCCAGGGGCCTGACGCAGGC
AAATATGGCGGCTTACCTCGGCGTCAGGCAGCAGACCTATGCCGAACTGGAAGCCAACCCTGCCGCGGCCAGCGTAGAGC
GGCTGTTCAAGGCGCTGCGCGTGCTTGGCGTGGAGATGGTCCTTTCCCCTGCGCCAGATACCGATATGCAGCCGGAGCCG
GAGCCTCCTTCCGGCTACGTGACGCCGCCGGAAAAGGACCCGCGCCGGGCTACCCAGGTCGAACAGCCGAGAATGCCCGC
GAAGCGCAAGGCAAGCCGCACCGCCCTCAAGACCGGCCAGCCAAAGCGGGAGGACTGGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References