Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 1809851..1811562 | Replicon | chromosome |
Accession | NZ_CP032519 | ||
Organism | Cupriavidus oxalaticus strain T2 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | D2917_RS21065 | Protein ID | WP_151071848.1 |
Coordinates | 1810234..1811562 (+) | Length | 443 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | D2917_RS21060 | Protein ID | WP_151071847.1 |
Coordinates | 1809851..1810231 (+) | Length | 127 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D2917_RS21045 | 1807584..1807895 | + | 312 | WP_151072848.1 | response regulator transcription factor | - |
D2917_RS21050 | 1807924..1808571 | - | 648 | WP_151071845.1 | response regulator transcription factor | - |
D2917_RS21055 | 1808618..1809478 | - | 861 | WP_151071846.1 | universal stress protein | - |
D2917_RS21060 | 1809851..1810231 | + | 381 | WP_151071847.1 | helix-turn-helix domain-containing protein | Antitoxin |
D2917_RS21065 | 1810234..1811562 | + | 1329 | WP_151071848.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
D2917_RS21070 | 1811687..1815217 | + | 3531 | WP_151071849.1 | adenylate/guanylate cyclase domain-containing protein | - |
D2917_RS21075 | 1815214..1815885 | + | 672 | WP_063238758.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 443 a.a. Molecular weight: 48689.47 Da Isoelectric Point: 8.1855
>T111926 WP_151071848.1 NZ_CP032519:1810234-1811562 [Cupriavidus oxalaticus]
MTRGTHAKRLDLWMNGLPVGHWETTPAGDRLAYREDWIADPQGRPLSLSLPFTPGNQPHRGPVVANYFDNLLPDSDAIRR
RIAARYQTGGTDAFALLARLGRDCAGALQMLPPQEAPTALKRVQGRPLSETEIATLLHEATDEPVLGLREPIDDLRLSIA
GAQEKTALLRWDGQWLLPQGSTPTTHIFKLPMGLVGNMRADMRTSVENEWLCARIVAAFGLPVAACEIARFGDTKALVVE
RFDRKPSADGSWLLRLPQEDMCQATGTPALQKYESDGGPGIQQIADILSGSRSAPSDRRNFFRAQIVFWLLAATDGHGKN
FSISHLPGSRYEATPLYDILSAHPIIGKGRNHVAPQRARLAMALHGKNSHYAIQEIQRRHWFAQGQRIGFPPGDVGSMLD
EVMSQTSRAIDAAASALPPEFPMDLADAIFDGMRRQQRRLAA
MTRGTHAKRLDLWMNGLPVGHWETTPAGDRLAYREDWIADPQGRPLSLSLPFTPGNQPHRGPVVANYFDNLLPDSDAIRR
RIAARYQTGGTDAFALLARLGRDCAGALQMLPPQEAPTALKRVQGRPLSETEIATLLHEATDEPVLGLREPIDDLRLSIA
GAQEKTALLRWDGQWLLPQGSTPTTHIFKLPMGLVGNMRADMRTSVENEWLCARIVAAFGLPVAACEIARFGDTKALVVE
RFDRKPSADGSWLLRLPQEDMCQATGTPALQKYESDGGPGIQQIADILSGSRSAPSDRRNFFRAQIVFWLLAATDGHGKN
FSISHLPGSRYEATPLYDILSAHPIIGKGRNHVAPQRARLAMALHGKNSHYAIQEIQRRHWFAQGQRIGFPPGDVGSMLD
EVMSQTSRAIDAAASALPPEFPMDLADAIFDGMRRQQRRLAA
Download Length: 1329 bp
>T111926 NZ_CP032519:1810234-1811562 [Cupriavidus oxalaticus]
ATGACGCGCGGCACGCACGCGAAGCGTCTCGACCTGTGGATGAACGGCTTGCCGGTGGGCCACTGGGAAACCACGCCCGC
CGGCGACCGGCTGGCCTATCGCGAAGACTGGATTGCCGACCCGCAAGGCCGGCCGCTGTCCTTGTCATTGCCCTTTACGC
CGGGCAACCAGCCACACCGCGGACCGGTAGTCGCCAACTATTTCGACAACCTGCTGCCCGACAGCGATGCCATCCGGCGG
CGCATCGCGGCCCGGTACCAGACCGGCGGGACCGACGCCTTCGCGCTGCTGGCCAGGCTCGGCCGCGACTGCGCCGGCGC
CCTGCAGATGCTGCCGCCGCAGGAAGCGCCGACGGCGTTGAAGCGCGTCCAGGGCCGCCCGCTGTCGGAAACGGAGATCG
CAACCCTGCTGCACGAGGCCACGGACGAGCCCGTGCTCGGGCTGCGCGAACCCATCGATGACCTGCGCCTGTCCATCGCC
GGTGCGCAGGAAAAGACCGCGCTGCTGCGCTGGGACGGGCAATGGCTGTTGCCGCAAGGCAGTACGCCTACCACGCATAT
CTTCAAGCTGCCGATGGGACTGGTGGGCAATATGCGCGCCGACATGCGGACCTCGGTGGAAAACGAATGGCTCTGCGCCA
GGATCGTCGCCGCGTTTGGCCTGCCGGTCGCTGCCTGCGAGATCGCCCGCTTCGGGGATACCAAGGCGCTGGTCGTCGAA
CGCTTCGACCGCAAGCCCTCGGCGGACGGTTCCTGGCTGCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCCACCGGGAC
GCCGGCATTGCAGAAGTACGAGTCGGACGGCGGGCCGGGCATCCAGCAGATCGCAGACATCCTCTCCGGCTCGCGCTCGG
CGCCGTCCGATCGCCGCAACTTCTTCCGCGCGCAGATCGTCTTCTGGCTGCTCGCGGCCACGGATGGCCATGGCAAGAAC
TTCAGCATCAGCCACCTGCCGGGCAGCCGCTATGAAGCGACGCCGCTGTACGACATCCTGTCGGCGCATCCGATCATCGG
CAAAGGCAGGAACCACGTGGCGCCGCAACGGGCCCGGCTGGCGATGGCGCTGCACGGCAAGAATTCGCACTACGCCATCC
AGGAGATCCAGCGGCGGCACTGGTTTGCCCAGGGACAGCGCATCGGCTTCCCGCCCGGCGATGTCGGGTCGATGCTCGAC
GAGGTCATGTCGCAGACCAGCCGGGCCATCGACGCCGCCGCTTCCGCGCTGCCGCCGGAATTCCCCATGGATCTTGCCGA
TGCGATCTTCGATGGCATGCGCCGGCAGCAGCGGCGTCTGGCCGCCTGA
ATGACGCGCGGCACGCACGCGAAGCGTCTCGACCTGTGGATGAACGGCTTGCCGGTGGGCCACTGGGAAACCACGCCCGC
CGGCGACCGGCTGGCCTATCGCGAAGACTGGATTGCCGACCCGCAAGGCCGGCCGCTGTCCTTGTCATTGCCCTTTACGC
CGGGCAACCAGCCACACCGCGGACCGGTAGTCGCCAACTATTTCGACAACCTGCTGCCCGACAGCGATGCCATCCGGCGG
CGCATCGCGGCCCGGTACCAGACCGGCGGGACCGACGCCTTCGCGCTGCTGGCCAGGCTCGGCCGCGACTGCGCCGGCGC
CCTGCAGATGCTGCCGCCGCAGGAAGCGCCGACGGCGTTGAAGCGCGTCCAGGGCCGCCCGCTGTCGGAAACGGAGATCG
CAACCCTGCTGCACGAGGCCACGGACGAGCCCGTGCTCGGGCTGCGCGAACCCATCGATGACCTGCGCCTGTCCATCGCC
GGTGCGCAGGAAAAGACCGCGCTGCTGCGCTGGGACGGGCAATGGCTGTTGCCGCAAGGCAGTACGCCTACCACGCATAT
CTTCAAGCTGCCGATGGGACTGGTGGGCAATATGCGCGCCGACATGCGGACCTCGGTGGAAAACGAATGGCTCTGCGCCA
GGATCGTCGCCGCGTTTGGCCTGCCGGTCGCTGCCTGCGAGATCGCCCGCTTCGGGGATACCAAGGCGCTGGTCGTCGAA
CGCTTCGACCGCAAGCCCTCGGCGGACGGTTCCTGGCTGCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCCACCGGGAC
GCCGGCATTGCAGAAGTACGAGTCGGACGGCGGGCCGGGCATCCAGCAGATCGCAGACATCCTCTCCGGCTCGCGCTCGG
CGCCGTCCGATCGCCGCAACTTCTTCCGCGCGCAGATCGTCTTCTGGCTGCTCGCGGCCACGGATGGCCATGGCAAGAAC
TTCAGCATCAGCCACCTGCCGGGCAGCCGCTATGAAGCGACGCCGCTGTACGACATCCTGTCGGCGCATCCGATCATCGG
CAAAGGCAGGAACCACGTGGCGCCGCAACGGGCCCGGCTGGCGATGGCGCTGCACGGCAAGAATTCGCACTACGCCATCC
AGGAGATCCAGCGGCGGCACTGGTTTGCCCAGGGACAGCGCATCGGCTTCCCGCCCGGCGATGTCGGGTCGATGCTCGAC
GAGGTCATGTCGCAGACCAGCCGGGCCATCGACGCCGCCGCTTCCGCGCTGCCGCCGGAATTCCCCATGGATCTTGCCGA
TGCGATCTTCGATGGCATGCGCCGGCAGCAGCGGCGTCTGGCCGCCTGA
Antitoxin
Download Length: 127 a.a. Molecular weight: 14128.20 Da Isoelectric Point: 10.4444
>AT111926 WP_151071847.1 NZ_CP032519:1809851-1810231 [Cupriavidus oxalaticus]
MHYSIQTLSQLRPILQGFRKSRGLTQANMAAYLGVRQQTYAELEANPAAASVERLFKALRVLGVEMVLSPAPDTDMQPEP
EPPSGYVTPPEKDPRRATQVEQPRMPAKRKASRTALKTGQPKREDW
MHYSIQTLSQLRPILQGFRKSRGLTQANMAAYLGVRQQTYAELEANPAAASVERLFKALRVLGVEMVLSPAPDTDMQPEP
EPPSGYVTPPEKDPRRATQVEQPRMPAKRKASRTALKTGQPKREDW
Download Length: 381 bp
>AT111926 NZ_CP032519:1809851-1810231 [Cupriavidus oxalaticus]
ATGCACTATTCCATCCAGACACTCAGCCAGCTGCGGCCGATCCTGCAGGGCTTCCGGAAATCCAGGGGCCTGACGCAGGC
AAATATGGCGGCTTACCTCGGCGTCAGGCAGCAGACCTATGCCGAACTGGAAGCCAACCCTGCCGCGGCCAGCGTAGAGC
GGCTGTTCAAGGCGCTGCGCGTGCTTGGCGTGGAGATGGTCCTTTCCCCTGCGCCAGATACCGATATGCAGCCGGAGCCG
GAGCCTCCTTCCGGCTACGTGACGCCGCCGGAAAAGGACCCGCGCCGGGCTACCCAGGTCGAACAGCCGAGAATGCCCGC
GAAGCGCAAGGCAAGCCGCACCGCCCTCAAGACCGGCCAGCCAAAGCGGGAGGACTGGTAG
ATGCACTATTCCATCCAGACACTCAGCCAGCTGCGGCCGATCCTGCAGGGCTTCCGGAAATCCAGGGGCCTGACGCAGGC
AAATATGGCGGCTTACCTCGGCGTCAGGCAGCAGACCTATGCCGAACTGGAAGCCAACCCTGCCGCGGCCAGCGTAGAGC
GGCTGTTCAAGGCGCTGCGCGTGCTTGGCGTGGAGATGGTCCTTTCCCCTGCGCCAGATACCGATATGCAGCCGGAGCCG
GAGCCTCCTTCCGGCTACGTGACGCCGCCGGAAAAGGACCCGCGCCGGGCTACCCAGGTCGAACAGCCGAGAATGCCCGC
GAAGCGCAAGGCAAGCCGCACCGCCCTCAAGACCGGCCAGCCAAAGCGGGAGGACTGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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