111923

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 664265..664805 Replicon chromosome
Accession NZ_CP032518
Organism Cupriavidus oxalaticus strain T2

Toxin (Protein)


Gene name brnT Uniprot ID A0A375GHM6
Locus tag D2917_RS02900 Protein ID WP_063240620.1
Coordinates 664265..664534 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A375GNI1
Locus tag D2917_RS02905 Protein ID WP_063240621.1
Coordinates 664518..664805 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D2917_RS02880 659376..660086 - 711 WP_063240616.1 uracil phosphoribosyltransferase -
D2917_RS02885 660186..661508 - 1323 WP_063240617.1 URC4/urg3 family protein -
D2917_RS02890 661505..662743 - 1239 WP_063240618.1 GTP cyclohydrolase II -
D2917_RS02895 662977..664086 - 1110 WP_151069517.1 acyltransferase -
D2917_RS02900 664265..664534 + 270 WP_063240620.1 BrnT family toxin Toxin
D2917_RS02905 664518..664805 + 288 WP_063240621.1 BrnA antitoxin family protein Antitoxin
D2917_RS02910 665043..665351 + 309 WP_063240622.1 hypothetical protein -
D2917_RS02915 665421..666323 - 903 WP_063240623.1 hypothetical protein -
D2917_RS02920 666725..668464 + 1740 WP_151069518.1 glycosyltransferase family 39 protein -
D2917_RS02925 668484..668855 + 372 WP_063240625.1 EamA family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-90)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10139.59 Da        Isoelectric Point: 8.0323

>T111923 WP_063240620.1 NZ_CP032518:664265-664534 [Cupriavidus oxalaticus]
MDITFDVAKDAANLSKHGLSLRVAAQLDWPAVMAGVDTRRDYREVREIGFGVIADRLYCVVFTQRGDAMHIISLRKANQR
EVRNYVEQT

Download         Length: 270 bp

>T111923 NZ_CP032518:664265-664534 [Cupriavidus oxalaticus]
ATGGACATCACCTTTGATGTAGCCAAGGACGCCGCCAATCTTTCCAAGCACGGCTTATCGCTACGCGTGGCCGCTCAACT
GGACTGGCCAGCGGTCATGGCGGGCGTTGATACCAGACGGGACTACAGGGAGGTGCGCGAAATCGGCTTTGGCGTGATTG
CCGATCGCCTCTATTGTGTGGTGTTCACTCAGCGTGGGGATGCGATGCACATCATCAGCCTGCGCAAGGCCAACCAACGC
GAGGTACGAAACTATGTCGAGCAAACCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10721.20 Da        Isoelectric Point: 8.5541

>AT111923 WP_063240621.1 NZ_CP032518:664518-664805 [Cupriavidus oxalaticus]
MSSKPKIVMPTDEEDAAINRGIATDPDTYEVSADEMMAMKPLGKRGRGRPRLGNTKELVSIRYDAEVLEAFRASGEGWQT
RMNSALKEWLRTHRP

Download         Length: 288 bp

>AT111923 NZ_CP032518:664518-664805 [Cupriavidus oxalaticus]
ATGTCGAGCAAACCTAAGATCGTGATGCCGACCGACGAGGAGGACGCGGCAATCAACCGCGGCATCGCCACCGATCCGGA
CACCTATGAAGTGTCGGCCGATGAAATGATGGCGATGAAGCCTCTTGGCAAACGCGGCCGGGGCCGGCCAAGACTGGGCA
ACACCAAGGAACTCGTCAGCATCCGCTACGATGCCGAAGTTCTGGAAGCTTTCCGTGCGAGCGGAGAAGGCTGGCAGACA
CGAATGAACAGCGCACTCAAAGAGTGGCTTCGCACGCACAGGCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375GHM6

Antitoxin

Source ID Structure
AlphaFold DB A0A375GNI1

References