111907

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2323679..2324510 Replicon chromosome
Accession NZ_CP032515
Organism Escherichia coli strain 118UI

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag Eco118UI_RS11810 Protein ID WP_000854814.1
Coordinates 2324136..2324510 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag Eco118UI_RS11805 Protein ID WP_001285585.1
Coordinates 2323679..2324047 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Eco118UI_RS11765 2319665..2320507 + 843 Protein_2229 hypothetical protein -
Eco118UI_RS11770 2320583..2321038 + 456 WP_000581504.1 hypothetical protein -
Eco118UI_RS11775 2321117..2321350 + 234 WP_001119729.1 DUF905 family protein -
Eco118UI_RS11785 2321450..2322268 + 819 WP_021538423.1 DUF945 domain-containing protein -
Eco118UI_RS11790 2322350..2322829 + 480 WP_000860074.1 antirestriction protein -
Eco118UI_RS11795 2322845..2323321 + 477 WP_001186726.1 RadC family protein -
Eco118UI_RS11800 2323384..2323605 + 222 WP_000692323.1 DUF987 domain-containing protein -
Eco118UI_RS11805 2323679..2324047 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
Eco118UI_RS11810 2324136..2324510 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
Eco118UI_RS11815 2324507..2324701 + 195 WP_000988600.1 hypothetical protein -
Eco118UI_RS11820 2324714..2324827 + 114 WP_001161660.1 DUF957 domain-containing protein -
Eco118UI_RS11825 2325116..2325244 - 129 Protein_2240 transposase domain-containing protein -
Eco118UI_RS11830 2325316..2325498 + 183 WP_032140263.1 ethanolamine utilization protein -
Eco118UI_RS11835 2325599..2325928 - 330 WP_000450409.1 DUF496 family protein -
Eco118UI_RS11840 2326100..2327158 - 1059 WP_001200891.1 FUSC family protein -
Eco118UI_RS11845 2327356..2327829 - 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
Eco118UI_RS11850 2327948..2329114 - 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T111907 WP_000854814.1 NZ_CP032515:2324136-2324510 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T111907 NZ_CP032515:2324136-2324510 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT111907 WP_001285585.1 NZ_CP032515:2323679-2324047 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT111907 NZ_CP032515:2323679-2324047 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References