Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2075548..2076343 | Replicon | chromosome |
| Accession | NZ_CP032513 | ||
| Organism | Shigella flexneri strain SFL1520 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q93EZ7 |
| Locus tag | D6T62_RS11275 | Protein ID | WP_000854917.1 |
| Coordinates | 2075548..2075922 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | D6T62_RS11280 | Protein ID | WP_001280959.1 |
| Coordinates | 2075969..2076343 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D6T62_RS11240 (2071158) | 2071158..2072096 | - | 939 | Protein_2150 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| D6T62_RS11250 (2072567) | 2072567..2072848 | - | 282 | Protein_2151 | DUF4942 domain-containing protein | - |
| D6T62_RS11255 (2073130) | 2073130..2074134 | - | 1005 | WP_134800001.1 | IS110-like element ISSfl8 family transposase | - |
| D6T62_RS11260 (2074206) | 2074206..2074766 | - | 561 | Protein_2153 | DUF4942 domain-containing protein | - |
| D6T62_RS11265 (2074851) | 2074851..2075048 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| D6T62_RS11270 (2075060) | 2075060..2075551 | - | 492 | WP_000976828.1 | DUF5983 family protein | - |
| D6T62_RS11275 (2075548) | 2075548..2075922 | - | 375 | WP_000854917.1 | TA system toxin CbtA family protein | Toxin |
| D6T62_RS11280 (2075969) | 2075969..2076343 | - | 375 | WP_001280959.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| D6T62_RS11285 (2076506) | 2076506..2076727 | - | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| D6T62_RS11290 (2076790) | 2076790..2077266 | - | 477 | WP_005011624.1 | RadC family protein | - |
| D6T62_RS11295 (2077282) | 2077282..2077755 | - | 474 | WP_005011597.1 | antirestriction protein | - |
| D6T62_RS11305 (2078097) | 2078097..2078918 | - | 822 | WP_001234584.1 | DUF932 domain-containing protein | - |
| D6T62_RS11310 (2079018) | 2079018..2079191 | - | 174 | WP_000088744.1 | DUF905 family protein | - |
| D6T62_RS24485 (2079311) | 2079311..2079574 | - | 264 | WP_000466628.1 | DNA polymerase III subunit gamma/tau | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(B) / catA1 / dfrA1 / ant(3'')-Ia | csgC / csgB / csgD / csgE / csgF / csgG / clbQ | 2062146..2144336 | 82190 | |
| - | flank | IS/Tn | - | - | 2073130..2074134 | 1004 | |
| - | flank | IS/Tn | - | - | 2079757..2080260 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14145.22 Da Isoelectric Point: 7.7761
>T111881 WP_000854917.1 NZ_CP032513:c2075922-2075548 [Shigella flexneri]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T111881 NZ_CP032513:c2075922-2075548 [Shigella flexneri]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13792.64 Da Isoelectric Point: 6.8407
>AT111881 WP_001280959.1 NZ_CP032513:c2076343-2075969 [Shigella flexneri]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT111881 NZ_CP032513:c2076343-2075969 [Shigella flexneri]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|