Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1572061..1572587 | Replicon | chromosome |
| Accession | NZ_CP032513 | ||
| Organism | Shigella flexneri strain SFL1520 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | D6T62_RS08500 | Protein ID | WP_000323025.1 |
| Coordinates | 1572300..1572587 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | D6T62_RS08495 | Protein ID | WP_000534858.1 |
| Coordinates | 1572061..1572300 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D6T62_RS08470 (1567164) | 1567164..1568632 | - | 1469 | Protein_1614 | mannitol dehydrogenase family protein | - |
| D6T62_RS08475 (1568748) | 1568748..1569445 | + | 698 | WP_252739182.1 | IS1 family transposase | - |
| D6T62_RS08480 (1569497) | 1569497..1570516 | - | 1020 | Protein_1616 | MHS family MFS transporter YdfJ | - |
| D6T62_RS08485 (1570578) | 1570578..1571734 | + | 1157 | WP_094099483.1 | IS3-like element IS600 family transposase | - |
| D6T62_RS08490 (1571731) | 1571731..1572036 | - | 306 | WP_071818640.1 | hypothetical protein | - |
| D6T62_RS08495 (1572061) | 1572061..1572300 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| D6T62_RS08500 (1572300) | 1572300..1572587 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| D6T62_RS08505 (1572659) | 1572659..1572814 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| D6T62_RS08510 (1573032) | 1573032..1573282 | + | 251 | Protein_1622 | hypothetical protein | - |
| D6T62_RS08515 (1573349) | 1573349..1573627 | + | 279 | WP_024258459.1 | hypothetical protein | - |
| D6T62_RS08520 (1573629) | 1573629..1574678 | + | 1050 | WP_001265241.1 | DUF968 domain-containing protein | - |
| D6T62_RS08525 (1574691) | 1574691..1575047 | + | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| D6T62_RS08530 (1575062) | 1575062..1575883 | + | 822 | WP_000762884.1 | antitermination protein | - |
| D6T62_RS08550 (1576825) | 1576825..1576911 | + | 87 | WP_000115835.1 | DUF3927 family protein | - |
| D6T62_RS08555 (1577192) | 1577192..1577527 | - | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1568942..1582354 | 13412 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T111878 WP_000323025.1 NZ_CP032513:1572300-1572587 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T111878 NZ_CP032513:1572300-1572587 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT111878 WP_000534858.1 NZ_CP032513:1572061-1572300 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT111878 NZ_CP032513:1572061-1572300 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|