Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 4051..4652 | Replicon | plasmid pSO21_75 |
| Accession | NZ_CP032497 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SO21 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A731GHK2 |
| Locus tag | D5069_RS24165 | Protein ID | WP_001216038.1 |
| Coordinates | 4051..4431 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | D5069_RS24170 | Protein ID | WP_001190712.1 |
| Coordinates | 4431..4652 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D5069_RS24130 | 168..1196 | + | 1029 | WP_001292231.1 | tyrosine-type recombinase/integrase | - |
| D5069_RS24135 | 1306..1614 | + | 309 | WP_000349257.1 | hypothetical protein | - |
| D5069_RS24140 | 1611..2087 | + | 477 | WP_001557738.1 | hypothetical protein | - |
| D5069_RS24145 | 2084..2578 | + | 495 | WP_001557737.1 | dUTP diphosphatase | - |
| D5069_RS24150 | 2593..3033 | + | 441 | WP_001557736.1 | DUF2829 domain-containing protein | - |
| D5069_RS24155 | 3040..3816 | + | 777 | WP_022630895.1 | hypothetical protein | - |
| D5069_RS24160 | 3849..4046 | - | 198 | WP_000113017.1 | hypothetical protein | - |
| D5069_RS24165 | 4051..4431 | - | 381 | WP_001216038.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| D5069_RS24170 | 4431..4652 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| D5069_RS24175 | 4761..5183 | - | 423 | WP_000098854.1 | hypothetical protein | - |
| D5069_RS24180 | 5318..5707 | - | 390 | WP_022630896.1 | DNA repair protein | - |
| D5069_RS24185 | 5719..5865 | - | 147 | WP_001443773.1 | hypothetical protein | - |
| D5069_RS24190 | 6039..6248 | + | 210 | WP_001344848.1 | hypothetical protein | - |
| D5069_RS24195 | 6233..6507 | - | 275 | Protein_13 | antitoxin PHD | - |
| D5069_RS24200 | 6853..7569 | - | 717 | Protein_14 | DUF551 domain-containing protein | - |
| D5069_RS24205 | 7580..8035 | - | 456 | WP_001142594.1 | DUF4014 family protein | - |
| D5069_RS24210 | 8037..8252 | - | 216 | WP_001557731.1 | hypothetical protein | - |
| D5069_RS24215 | 8254..8445 | - | 192 | WP_001557730.1 | hypothetical protein | - |
| D5069_RS24220 | 8432..9079 | - | 648 | WP_000034256.1 | ead/Ea22-like family protein | - |
| D5069_RS24225 | 9066..9365 | - | 300 | WP_046891370.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..74729 | 74729 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 18709.44 Da Isoelectric Point: 5.5500
>T111858 WP_001216038.1 NZ_CP032497:c4431-4051 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 381 bp
>T111858 NZ_CP032497:c4431-4051 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin
Download Length: 74 a.a. Molecular weight: 10909.08 Da Isoelectric Point: 5.5500
>AT111858 WP_001190712.1 NZ_CP032497:c4652-4431 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Download Length: 222 bp
>AT111858 NZ_CP032497:c4652-4431 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A731GHK2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |