Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
Location | 87396..87997 | Replicon | plasmid pSL26_91 |
Accession | NZ_CP032492 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SL26 |
Toxin (Protein)
Gene name | doc | Uniprot ID | A0A731GHK2 |
Locus tag | D5068_RS24980 | Protein ID | WP_001216038.1 |
Coordinates | 87617..87997 (+) | Length | 127 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | U9YQH9 |
Locus tag | D5068_RS24975 | Protein ID | WP_001190712.1 |
Coordinates | 87396..87617 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D5068_RS24920 | 82683..82982 | + | 300 | WP_046891370.1 | hypothetical protein | - |
D5068_RS24925 | 82969..83616 | + | 648 | WP_000034256.1 | ead/Ea22-like family protein | - |
D5068_RS24930 | 83603..83794 | + | 192 | WP_001557730.1 | hypothetical protein | - |
D5068_RS24935 | 83796..84011 | + | 216 | WP_001557731.1 | hypothetical protein | - |
D5068_RS24940 | 84013..84468 | + | 456 | WP_001142594.1 | DUF4014 family protein | - |
D5068_RS24945 | 84479..85195 | + | 717 | Protein_98 | DUF551 domain-containing protein | - |
D5068_RS24950 | 85541..85815 | + | 275 | Protein_99 | antitoxin PHD | - |
D5068_RS24955 | 85800..86009 | - | 210 | WP_001344848.1 | hypothetical protein | - |
D5068_RS24960 | 86183..86329 | + | 147 | WP_001443773.1 | hypothetical protein | - |
D5068_RS24965 | 86341..86730 | + | 390 | WP_022630896.1 | DNA repair protein | - |
D5068_RS24970 | 86865..87287 | + | 423 | WP_000098854.1 | hypothetical protein | - |
D5068_RS24975 | 87396..87617 | + | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
D5068_RS24980 | 87617..87997 | + | 381 | WP_001216038.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
D5068_RS24985 | 88002..88199 | + | 198 | WP_000113017.1 | hypothetical protein | - |
D5068_RS24990 | 88232..89008 | - | 777 | WP_022630895.1 | hypothetical protein | - |
D5068_RS24995 | 89015..89455 | - | 441 | WP_001557736.1 | DUF2829 domain-containing protein | - |
D5068_RS25000 | 89470..89964 | - | 495 | WP_001557737.1 | dUTP diphosphatase | - |
D5068_RS25005 | 89961..90437 | - | 477 | WP_001557738.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..90686 | 90686 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 16296.13 Da Isoelectric Point: 12.9004
>T111856 WP_001216038.1 NZ_CP032492:87617-87997 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
Download Length: 381 bp
>T111856 NZ_CP032492:87617-87997 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 9502.90 Da Isoelectric Point: 12.6633
>AT111856 WP_001190712.1 NZ_CP032492:87396-87617 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
Download Length: 222 bp
>AT111856 NZ_CP032492:87396-87617 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A731GHK2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CJB6 |