Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 87396..87997 Replicon plasmid pSL26_91
Accession NZ_CP032492
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SL26

Toxin (Protein)


Gene name doc Uniprot ID A0A731GHK2
Locus tag D5068_RS24980 Protein ID WP_001216038.1
Coordinates 87617..87997 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag D5068_RS24975 Protein ID WP_001190712.1
Coordinates 87396..87617 (+) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5068_RS24920 82683..82982 + 300 WP_046891370.1 hypothetical protein -
D5068_RS24925 82969..83616 + 648 WP_000034256.1 ead/Ea22-like family protein -
D5068_RS24930 83603..83794 + 192 WP_001557730.1 hypothetical protein -
D5068_RS24935 83796..84011 + 216 WP_001557731.1 hypothetical protein -
D5068_RS24940 84013..84468 + 456 WP_001142594.1 DUF4014 family protein -
D5068_RS24945 84479..85195 + 717 Protein_98 DUF551 domain-containing protein -
D5068_RS24950 85541..85815 + 275 Protein_99 antitoxin PHD -
D5068_RS24955 85800..86009 - 210 WP_001344848.1 hypothetical protein -
D5068_RS24960 86183..86329 + 147 WP_001443773.1 hypothetical protein -
D5068_RS24965 86341..86730 + 390 WP_022630896.1 DNA repair protein -
D5068_RS24970 86865..87287 + 423 WP_000098854.1 hypothetical protein -
D5068_RS24975 87396..87617 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D5068_RS24980 87617..87997 + 381 WP_001216038.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
D5068_RS24985 88002..88199 + 198 WP_000113017.1 hypothetical protein -
D5068_RS24990 88232..89008 - 777 WP_022630895.1 hypothetical protein -
D5068_RS24995 89015..89455 - 441 WP_001557736.1 DUF2829 domain-containing protein -
D5068_RS25000 89470..89964 - 495 WP_001557737.1 dUTP diphosphatase -
D5068_RS25005 89961..90437 - 477 WP_001557738.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90686 90686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-119)

Antitoxin

(2-46)


Sequences


Toxin        


Download         Length: 127 a.a.        Molecular weight: 16296.13 Da        Isoelectric Point: 12.9004

>T111856 WP_001216038.1 NZ_CP032492:87617-87997 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 381 bp

>T111856 NZ_CP032492:87617-87997 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 9502.90 Da        Isoelectric Point: 12.6633

>AT111856 WP_001190712.1 NZ_CP032492:87396-87617 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 222 bp

>AT111856 NZ_CP032492:87396-87617 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A731GHK2


Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References