Detailed information of TA system TA111852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1744082..1745074
• Replicon: chromosome
• Accession: NZ_CP032487
• Organism: Yersinia hibernica strain CFS1934

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: D5F51_RS08270
• Protein ID: WP_129196118.1
• Coordinates: 1744082..1744540 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: D5F51_RS08275
• Protein ID: WP_025378340.1
• Coordinates: 1744628..1745074 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5F51_RS08240	1739983..1740648	+	666	WP_129196115.1	phage shock protein PspA	-
D5F51_RS08245	1740758..1740985	+	228	WP_005161022.1	envelope stress response membrane protein PspB	-
D5F51_RS08250	1740985..1741359	+	375	WP_162301710.1	envelope stress response membrane protein PspC	-
D5F51_RS08255	1741400..1741639	+	240	WP_025378343.1	phage shock protein PspD	-
D5F51_RS08260	1741620..1743017	+	1398	WP_129196116.1	YcjX family protein	-
D5F51_RS08265	1743014..1744078	+	1065	WP_129196117.1	YcjF family protein	-
D5F51_RS08270	1744082..1744540	-	459	WP_129196118.1	RES family NAD+ phosphorylase	Toxin
D5F51_RS08275	1744628..1745074	-	447	WP_025378340.1	DUF2384 domain-containing protein	Antitoxin
D5F51_RS08280	1745395..1746972	+	1578	WP_129196119.1	transcriptional regulator TyrR	-
D5F51_RS08285	1747070..1747573	-	504	WP_025378338.1	thiol peroxidase	-
D5F51_RS08290	1747727..1748698	+	972	WP_129196120.1	L-Ala-D/L-Glu epimerase	-
D5F51_RS08295	1748695..1749402	-	708	WP_129199268.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-146)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17283.72 Da
• Isoelectric Point: 4.9038

>T111852 WP_129196118.1 NZ_CP032487:c1744540-1744082 [Yersinia hibernica]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPL
DWPTDWRNDPAPATTMDIGTEWLESESSLGLLVPSTLVPSENNLLLNPRHKDFQTSLHSVKPLSFAFDARLK

Nucleotide

• Length: 459 bp

>T111852 NZ_CP032487:c1744540-1744082 [Yersinia hibernica]
ATGATGCTCTATCGCATCGTGATGCGCCGCTATCTTGCATCAACCTGGACTGGTTATGGCGCTGAAATCTATGGCGGCCG
GTGGAATCATAAGGGGCATGCTGCCATTTACTTAGCCAGCAGTATATCGTTGGCGATGTTAGAGACATTGGTACATATTC
AGGACAGCTCCACGCTGAGTGAATTCGAGTTATTCCAGATTGAAATTGAAGATAGCAATATTATGCTGCTTCAGCCGCTG
GATTGGCCGACGGACTGGCGCAATGACCCGGCACCTGCGACGACAATGGATATCGGCACCGAATGGCTGGAATCAGAATC
ATCACTTGGATTGCTGGTTCCATCCACGCTGGTGCCATCAGAAAATAATCTACTACTCAACCCGCGACATAAAGATTTCC
AAACTAGCTTACACAGTGTCAAACCACTCTCTTTTGCCTTTGACGCGCGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16292.74 Da
• Isoelectric Point: 9.8753

>AT111852 WP_025378340.1 NZ_CP032487:c1745074-1744628 [Yersinia hibernica]
MRTYHPTPASKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDGIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRRPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT111852 NZ_CP032487:c1745074-1744628 [Yersinia hibernica]
ATGAGAACATATCACCCCACCCCAGCCAGTAAAACAGGGGCGCTATGGCGAGAAATCGGTTTGCCAGCCAGCCGCGGTAC
GGTATTAGTCGATAGCATCAAAATGGGCTTTTCTGTTGATGTCATTGACGGTATCCATCTATGGGCATCTATCCCTAAAG
CTGAAATCTTACGGGCGACCGGTATTCCCAGCCGCAGTTTGACACGTCGGCGCACCCATGACGGCCGTTTCACCCCTGAA
GAAAGTGAGCGAATTGCGCGTTTCGTCCGGGTAATGGATGCGGCAGTTGATCTGTTTGGCGGTGATAAAGGCAAGGCGAT
TACTTGGATGTCGACCCCGATTAAAGGCCTTGGTCACCGCAGGCCGGACTCCTTACTGGAGACTGAAACCGGTGCATTAG
AAGTCTGCGATTTAATTGGGCGCTTGGAGCACGGTGTATTTTCATAA