Detailed information of TA system TA111843

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 608227..608950
• Replicon: chromosome
• Accession: NZ_CP032487
• Organism: Yersinia hibernica strain CFS1934

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A481Q9T8
• Locus tag: D5F51_RS02910
• Protein ID: WP_053266278.1
• Coordinates: 608630..608950 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: D5F51_RS02905
• Protein ID: WP_105607669.1
• Coordinates: 608227..608562 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5F51_RS02865	603903..604728	+	826	Protein_525	DUF945 domain-containing protein	-
D5F51_RS02870	604945..605646	+	702	WP_129195551.1	WYL domain-containing protein	-
D5F51_RS02875	605687..605923	+	237	WP_032181217.1	hypothetical protein	-
D5F51_RS02880	605923..606366	+	444	WP_105607671.1	hypothetical protein	-
D5F51_RS02885	606390..606857	+	468	WP_129195552.1	hypothetical protein	-
D5F51_RS02890	606934..607173	+	240	WP_129195553.1	DUF905 domain-containing protein	-
D5F51_RS02895	607273..607722	+	450	WP_129195554.1	antirestriction protein	-
D5F51_RS02900	607734..608213	+	480	WP_102217336.1	DNA repair protein RadC	-
D5F51_RS02905	608227..608562	+	336	WP_105607669.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
D5F51_RS02910	608630..608950	+	321	WP_053266278.1	TA system toxin CbtA family protein	Toxin
D5F51_RS02915	609516..609665	+	150	Protein_535	DUF4102 domain-containing protein	-
D5F51_RS02920	609782..610000	-	219	WP_129195555.1	hypothetical protein	-
D5F51_RS02925	610962..611372	+	411	WP_025379635.1	GNAT family N-acetyltransferase	-
D5F51_RS02930	611398..612087	+	690	WP_025379634.1	PAS and helix-turn-helix domain-containing protein	-
D5F51_RS02935	612108..613415	+	1308	WP_025379633.1	cytosine permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12096.82 Da
• Isoelectric Point: 6.4799

>T111843 WP_053266278.1 NZ_CP032487:608630-608950 [Yersinia hibernica]
MQISTVPATMPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIKEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQEQTPFVTATDILRARRATGLMNK

Nucleotide

• Length: 321 bp

>T111843 NZ_CP032487:608630-608950 [Yersinia hibernica]
ATGCAAATCTCAACTGTACCGGCCACGATGCCGGTTTCGTCACGCCTGTCGCCCGTGCAGGTCTGGCAGCAATTGTTAAC
GTATCTGCTGGAGCACCATTACGGCCTGACGCTCAACGACACACCATTCCATGATGATGCGGCCATCAAGGAACATATCG
AGGCGGGTATCACGCTTGCTGATGCGGTGAATTTCCTGGTGGAACGTTATGAACTGGTACGCACTGATCGCAAGGGGTTT
ACGTGGCAGGAGCAGACACCATTTGTAACCGCTACAGATATTCTCAGAGCCAGAAGAGCTACCGGGCTGATGAATAAGTA
A

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12594.36 Da
• Isoelectric Point: 7.0262

>AT111843 WP_105607669.1 NZ_CP032487:608227-608562 [Yersinia hibernica]
MYKDATPTWGLRRDITPCFGARLVQEGHRLHFLANRAGFTGSFSEVQTLQLNEAFPHFVAYLELMLLSCELNPRYAHCVT
LYRNGLTCEADTLGSHGHVYMAIYPSNQVKD

Nucleotide

• Length: 336 bp

>AT111843 NZ_CP032487:608227-608562 [Yersinia hibernica]
ATGTATAAAGACGCTACACCAACCTGGGGGCTTAGACGAGATATCACTCCGTGTTTCGGAGCCCGACTGGTGCAGGAAGG
TCATCGCCTGCATTTTCTGGCTAACCGGGCAGGATTCACCGGCTCATTCAGTGAGGTGCAGACCTTACAACTGAATGAAG
CCTTCCCGCATTTTGTCGCATATCTGGAGCTGATGCTGCTCTCCTGCGAGCTGAATCCCCGGTACGCGCACTGTGTCACA
CTGTACCGTAACGGGTTGACTTGTGAAGCAGATACGCTGGGCAGTCATGGGCACGTGTATATGGCAATTTATCCCTCAAA
TCAGGTTAAAGACTGA

Structures

Toxin

• AlphaFold DB: A0A481Q9T8