Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2129694..2130208 Replicon chromosome
Accession NZ_CP032481
Organism Staphylococcus aureus strain O326

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag SaO326_RS10910 Protein ID WP_000603099.1
Coordinates 2129694..2129903 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag SaO326_RS10915 Protein ID WP_000138933.1
Coordinates 2129915..2130208 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO326_RS10890 2125202..2126560 - 1359 WP_000611458.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SaO326_RS10895 2126575..2127645 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SaO326_RS10900 2127963..2129165 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SaO326_RS10905 2129429..2129566 - 138 WP_000828354.1 hypothetical protein -
SaO326_RS10910 2129694..2129903 - 210 WP_000603099.1 heavy-metal-associated domain-containing protein Toxin
SaO326_RS10915 2129915..2130208 - 294 WP_000138933.1 copper-sensing transcriptional repressor CsoR Antitoxin
SaO326_RS10920 2130374..2131858 + 1485 WP_000571551.1 cardiolipin synthase -
SaO326_RS10925 2131886..2132548 + 663 WP_001187618.1 HD domain-containing protein -
SaO326_RS10940 2133299..2134171 - 873 WP_000725802.1 membrane protein insertase YidC -
SaO326_RS10945 2134257..2134898 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7819.79 Da        Isoelectric Point: 3.9389

>T111839 WP_000603099.1 NZ_CP032481:c2129903-2129694 [Staphylococcus aureus]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T111839 NZ_CP032481:c2129903-2129694 [Staphylococcus aureus]
ATGATACTTCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.81 Da        Isoelectric Point: 6.7122

>AT111839 WP_000138933.1 NZ_CP032481:c2130208-2129915 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT111839 NZ_CP032481:c2130208-2129915 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATAAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References