Detailed information of TA system TA111821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 960599..961205
• Replicon: chromosome
• Accession: NZ_CP032475
• Organism: Helicobacter pylori strain 381-F-EK9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D4K88_RS04760
• Protein ID: WP_201736709.1
• Coordinates: 960599..960856 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D4K88_RS04765
• Protein ID: WP_139532315.1
• Coordinates: 960840..961205 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4K88_RS04740	957239..958006	-	768	WP_000242355.1	ABC transporter ATP-binding protein	-
D4K88_RS04745	958006..958986	-	981	WP_000921458.1	iron ABC transporter permease	-
D4K88_RS04750	958979..959827	-	849	WP_139532313.1	SDR family oxidoreductase	-
D4K88_RS04755	959967..960491	+	525	WP_100978401.1	acyl-CoA thioesterase	-
D4K88_RS04760	960599..960856	-	258	WP_201736709.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D4K88_RS04765	960840..961205	-	366	WP_139532315.1	hypothetical protein	Antitoxin
D4K88_RS04770	962123..964315	-	2193	WP_139532316.1	Hop family adhesin BabA	-
D4K88_RS04785	964964..965598	+	635	Protein_903	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10006.77 Da
• Isoelectric Point: 7.2779

>T111821 WP_201736709.1 NZ_CP032475:c960856-960599 [Helicobacter pylori]
MKLNLKKSFQKDFDKLLLNGFDDSVLNEVILRKKEPLDPPFKDHALKGKWKPFRECHIKADILLVYLVEDDELILLRLGS
HSELF

Nucleotide

• Length: 258 bp

>T111821 NZ_CP032475:c960856-960599 [Helicobacter pylori]
TTGAAGCTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTTGAA
TGAAGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACCATTTAAAGATCATGCTTTAAAGGGAAAGTGGAAGCCTTTTA
GGGAATGCCATATTAAAGCCGACATTTTGCTTGTGTATTTAGTGGAAGATGATGAGCTGATTTTGTTAAGACTAGGCAGT
CATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 14396.34 Da
• Isoelectric Point: 8.4414

>AT111821 WP_139532315.1 NZ_CP032475:c961205-960840 [Helicobacter pylori]
MPNTTNKDYTKYSQRQLFNLMNKKEQEIEKLKRDRAYLEKKMAKELEKKDKGFTIKLEELNKILQEINKRANDCCFGHET
PNIQTQQAMRDVYNKETDLIVEDFSSYSDERKRALGVEAQP

Nucleotide

• Length: 366 bp

>AT111821 NZ_CP032475:c961205-960840 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAGACAGCTTTTTAACCTCATGAATAAGAAAGAACAAGA
AATTGAAAAGCTAAAAAGGGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAGGCTTCA
CTATCAAATTAGAAGAATTGAATAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAACATTCAAACGCAACAAGCCATGAGAGATGTGTATAACAAAGAGACAGATTTGATTGTTGAGGATTTTTCTAGTTA
CAGCGATGAAAGAAAAAGGGCTTTAGGTGTTGAAGCTCAACCTTAA