Detailed information of TA system TA111819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 974285..974937
• Replicon: chromosome
• Accession: NZ_CP032474
• Organism: Helicobacter pylori strain 476-C-EK5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D4L09_RS04865
• Protein ID: WP_139542130.1
• Coordinates: 974677..974937 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D4L09_RS04860
• Protein ID: WP_139542129.1
• Coordinates: 974285..974596 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4L09_RS04835	970656..971423	-	768	WP_000242353.1	ABC transporter ATP-binding protein	-
D4L09_RS04840	971423..972403	-	981	WP_000921458.1	iron ABC transporter permease	-
D4L09_RS04845	972396..973250	-	855	WP_139542127.1	SDR family oxidoreductase	-
D4L09_RS04850	973390..973914	+	525	WP_120929831.1	acyl-CoA thioesterase	-
D4L09_RS04855	973960..974298	-	339	WP_139542128.1	type II toxin-antitoxin system YafQ family toxin	-
D4L09_RS04860	974285..974596	-	312	WP_139542129.1	hypothetical protein	Antitoxin
D4L09_RS04865	974677..974937	-	261	WP_139542130.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D4L09_RS04870	974918..975292	-	375	WP_139542131.1	hypothetical protein	-
D4L09_RS04875	975776..978010	-	2235	WP_139548965.1	Hop family adhesin BabA	-
D4L09_RS04890	978660..979307	+	648	Protein_925	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10131.93 Da
• Isoelectric Point: 9.0167

>T111819 WP_139542130.1 NZ_CP032474:c974937-974677 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILRKKEPLDPRFQDHALKGKWKPFRECHIKADILLVYLVKDDELVLLRLG
SHSELF

Nucleotide

• Length: 261 bp

>T111819 NZ_CP032474:c974937-974677 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTCCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACGATTTCAAGATCATGCTCTAAAAGGCAAGTGGAAACCTT
TTAGGGAATGCCATATTAAAGCCGACATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTGTTTTGTTAAGACTAGGC
AGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12308.08 Da
• Isoelectric Point: 10.0586

>AT111819 WP_139542129.1 NZ_CP032474:c974596-974285 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILSRAEDTKNH
LCFKSIEDFKKHCENLRFKNADN

Nucleotide

• Length: 312 bp

>AT111819 NZ_CP032474:c974596-974285 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAGCAAAGGATTAAAAAAGCACTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGGTACACCATAGAAGAAGAGCGAGAAATCTTATCAAGGGCTGAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCATAGAGGATTTTAAGAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATAATTGA