Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1019083..1019735 Replicon chromosome
Accession NZ_CP032473
Organism Helicobacter pylori strain 476-A2-EK2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D4L01_RS05020 Protein ID WP_139542130.1
Coordinates 1019475..1019735 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D4L01_RS05015 Protein ID WP_139542129.1
Coordinates 1019083..1019394 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4L01_RS04990 1015454..1016221 - 768 WP_000242353.1 ABC transporter ATP-binding protein -
D4L01_RS04995 1016221..1017201 - 981 WP_000921458.1 iron ABC transporter permease -
D4L01_RS05000 1017194..1018048 - 855 WP_139542127.1 SDR family oxidoreductase -
D4L01_RS05005 1018188..1018712 + 525 WP_120929831.1 acyl-CoA thioesterase -
D4L01_RS05010 1018758..1019096 - 339 WP_139542128.1 type II toxin-antitoxin system YafQ family toxin -
D4L01_RS05015 1019083..1019394 - 312 WP_139542129.1 hypothetical protein Antitoxin
D4L01_RS05020 1019475..1019735 - 261 WP_139542130.1 type II toxin-antitoxin system YafQ family toxin Toxin
D4L01_RS05025 1019716..1020090 - 375 WP_139542131.1 hypothetical protein -
D4L01_RS05030 1020574..1022808 - 2235 WP_139542132.1 Hop family adhesin BabA -
D4L01_RS05045 1023519..1024166 + 648 Protein_956 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10131.93 Da        Isoelectric Point: 9.0167

>T111816 WP_139542130.1 NZ_CP032473:c1019735-1019475 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILRKKEPLDPRFQDHALKGKWKPFRECHIKADILLVYLVKDDELVLLRLG
SHSELF

Download         Length: 261 bp

>T111816 NZ_CP032473:c1019735-1019475 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTCCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACGATTTCAAGATCATGCTCTAAAAGGCAAGTGGAAACCTT
TTAGGGAATGCCATATTAAAGCCGACATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTGTTTTGTTAAGACTAGGC
AGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12308.08 Da        Isoelectric Point: 10.0586

>AT111816 WP_139542129.1 NZ_CP032473:c1019394-1019083 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILSRAEDTKNH
LCFKSIEDFKKHCENLRFKNADN

Download         Length: 312 bp

>AT111816 NZ_CP032473:c1019394-1019083 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAGCAAAGGATTAAAAAAGCACTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGGTACACCATAGAAGAAGAGCGAGAAATCTTATCAAGGGCTGAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCATAGAGGATTTTAAGAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References