Detailed information of TA system TA111816

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 1019083..1019735
• Replicon: chromosome
• Accession: NZ_CP032473
• Organism: Helicobacter pylori strain 476-A2-EK2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D4L01_RS05020
• Protein ID: WP_139542130.1
• Coordinates: 1019475..1019735 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D4L01_RS05015
• Protein ID: WP_139542129.1
• Coordinates: 1019083..1019394 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4L01_RS04990	1015454..1016221	-	768	WP_000242353.1	ABC transporter ATP-binding protein	-
D4L01_RS04995	1016221..1017201	-	981	WP_000921458.1	iron ABC transporter permease	-
D4L01_RS05000	1017194..1018048	-	855	WP_139542127.1	SDR family oxidoreductase	-
D4L01_RS05005	1018188..1018712	+	525	WP_120929831.1	acyl-CoA thioesterase	-
D4L01_RS05010	1018758..1019096	-	339	WP_139542128.1	type II toxin-antitoxin system YafQ family toxin	-
D4L01_RS05015	1019083..1019394	-	312	WP_139542129.1	hypothetical protein	Antitoxin
D4L01_RS05020	1019475..1019735	-	261	WP_139542130.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D4L01_RS05025	1019716..1020090	-	375	WP_139542131.1	hypothetical protein	-
D4L01_RS05030	1020574..1022808	-	2235	WP_139542132.1	Hop family adhesin BabA	-
D4L01_RS05045	1023519..1024166	+	648	Protein_956	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10131.93 Da
• Isoelectric Point: 9.0167

>T111816 WP_139542130.1 NZ_CP032473:c1019735-1019475 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILRKKEPLDPRFQDHALKGKWKPFRECHIKADILLVYLVKDDELVLLRLG
SHSELF

Nucleotide

• Length: 261 bp

>T111816 NZ_CP032473:c1019735-1019475 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTCCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACGATTTCAAGATCATGCTCTAAAAGGCAAGTGGAAACCTT
TTAGGGAATGCCATATTAAAGCCGACATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTGTTTTGTTAAGACTAGGC
AGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12308.08 Da
• Isoelectric Point: 10.0586

>AT111816 WP_139542129.1 NZ_CP032473:c1019394-1019083 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILSRAEDTKNH
LCFKSIEDFKKHCENLRFKNADN

Nucleotide

• Length: 312 bp

>AT111816 NZ_CP032473:c1019394-1019083 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAGCAAAGGATTAAAAAAGCACTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGGTACACCATAGAAGAAGAGCGAGAAATCTTATCAAGGGCTGAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCATAGAGGATTTTAAGAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATAATTGA